Loss of control (LOC) while eating (i.e., the sense that one cannot control what or how much one is eating) is prevalent among children and adolescents. LOC eating is associated with a range of physical and psychosocial health impairments, including obesity and the development of partial- and full-syndrome eating disorders. Early identification is thus critical for preventing or minimizing these adverse health outcomes. However, little is known about the development of LOC eating in children and, consequently, there is a paucity of effective interventions. Impairments in emotion regulation appear to be involved in the onset and maintenance of eating pathology in obese samples. To date, emotion regulation in youth with LOC eating problems is poorly understood, and research on underlying neurodevelopmental substrates is virtually nonexistent. The proposed research aims to characterize neurocircuitry involved in emotion regulation among 30 overweight children with LOC eating as compared to 30 overweight and 15 normal-weight controls without LOC. Participants will complete a cognitive reappraisal task whilst situated in an MRI scanner, the purpose of which is to characterize neural activity involved in reappraisal versus an emotion maintenance control condition. The proposed research aims to advance the field's understanding of the nature and correlates of LOC eating in overweight children so as to inform intervention development. The research also fits within the broader context of the applicant's career development goals. The candidate is an Assistant Professor of Psychiatry and Behavioral Neuroscience whose research program has focused on pediatric eating and weight disorders, particularly binge eating and its relationship with negative affect. The overarching goal of the 4-year training program is to establish the candidate as an independent investigator. Specific training activities will focus on gaining a sufficient understanding of neurocircuitry involved in emotion regulation across childhood and adolescence to be able to utilize a developmental neuroscience framework for the probing of dysregulated eating; and obtaining experience collecting, analyzing, and interpreting fMRI data. The mentorship team consists of internationally-known experts in developmental psychopathology, affective neuroscience, and pediatric eating and weight disorders who will provide conceptual oversight of the training plan and nurture the applicant's career trajectory. Research and training activities will be carried out at the University of Chicago's Department of Psychiatry and Behavioral Neuroscience and Brain Imaging Research Center. This Career Development Award will fill gaps in the candidate's training in order to broaden her expertise in pediatric obesity and eating disorders, ultimately guiding the research program towards the development of novel interventions for these problems, and facilitating her transition into an independent clinical investigator.

Public Health Relevance

Loss of control eating, or the sense that one cannot control what or how much one is eating, is prevalent among overweight children, and is associated with serious medical and psychosocial health complications. Although preliminary data suggest that youth with loss of control eating may have difficulties regulating their emotions, there is dearth f research concerning underlying neurodevelopmental factors. The proposed study aims to characterize neurodevelopmental substrates of emotion regulation in overweight children with loss of control eating, which could help guide research efforts towards the development of effective prevention and intervention strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23DK105234-05
Application #
9492561
Study Section
Kidney, Urologic and Hematologic Diseases D Subcommittee (DDK)
Program Officer
Saslowsky, David E
Project Start
2015-06-01
Project End
2019-05-31
Budget Start
2018-06-01
Budget End
2019-05-31
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Miriam Hospital
Department
Type
DUNS #
063902704
City
Providence
State
RI
Country
United States
Zip Code
Goldschmidt, Andrea B; Wall, Melanie M; Choo, Tse-Hwei J et al. (2018) Fifteen-year Weight and Disordered Eating Patterns Among Community-based Adolescents. Am J Prev Med 54:e21-e29
Goldschmidt, Andrea B; Khoury, Jane; Jenkins, Todd M et al. (2018) Adolescent Loss-of-Control Eating and Weight Loss Maintenance After Bariatric Surgery. Pediatrics 141:
Bodell, Lindsay P; Wildes, Jennifer E; Cheng, Yu et al. (2018) Associations between Race and Eating Disorder Symptom Trajectories in Black and White Girls. J Abnorm Child Psychol 46:625-638
Goldschmidt, Andrea B; Smith, Kathryn E; Lavender, Jason M et al. (2018) Trait-level facets of impulsivity and momentary, naturalistic eating behavior in children and adolescents with overweight/obesity. J Psychiatr Res 110:24-30
Bodell, Lindsay P; Wildes, Jennifer E; Goldschmidt, Andrea B et al. (2018) Associations Between Neural Reward Processing and Binge Eating Among Adolescent Girls. J Adolesc Health 62:107-113
Sharpe, Helen; Patalay, Praveetha; Choo, Tse-Hwei et al. (2018) Bidirectional associations between body dissatisfaction and depressive symptoms from adolescence through early adulthood. Dev Psychopathol 30:1447-1458
Goldschmidt, Andrea B; Smith, Kathryn E; Crosby, Ross D et al. (2018) Ecological momentary assessment of maladaptive eating in children and adolescents with overweight or obesity. Int J Eat Disord 51:549-557
Egbert, Amy Heard; Wilfley, Denise E; Eddy, Kamryn T et al. (2018) Attention-Deficit/Hyperactivity Disorder Symptoms Are Associated with Overeating with and without Loss of Control in Youth with Overweight/Obesity. Child Obes 14:50-57
Goldschmidt, Andrea B; Dickstein, Daniel P; MacNamara, Annmarie E et al. (2018) A Pilot Study of Neural Correlates of Loss of Control Eating in Children With Overweight/Obesity: Probing Intermittent Access to Food as a Means of Eliciting Disinhibited Eating. J Pediatr Psychol 43:846-855
Goldschmidt, Andrea B; O'Brien, Setareh; Lavender, Jason M et al. (2018) Executive functioning in a racially diverse sample of children who are overweight and at risk for eating disorders. Appetite 124:43-49

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