The candidate for this K23 Patient Oriented Research Career Development Award aims to become an international leader in pediatric nephrolithiasis research, with particular expertise in using innovative interventions to increase treatment adherence and decrease kidney stone recurrence among adolescents. The proposed mentored research and career development plan facilitates this career goal by identifying and mitigating risk factors for dehydration-mediated nephrolithiasis in adolescents. High and low ambient temperatures lead to dehydration and increase nephrolithiasis risk among adults, but the effect of temperature on stone risk in adolescents, who are particularly susceptible to temperature extremes, is unknown. Water is a cost-effective way to decrease kidney stone occurrence; however, despite dehydration being common among adolescents with stones, no studies have identified barriers to water intake or developed interventions to increase water intake in this population.
Aim 1 will determine differences in the temperature thresholds associated with kidney stone presentation among adolescents and adults.
Aim 2 will identify barriers to water intake among adolescents with kidney stones using real-time data gathered through mobile devices.
Aim 3 will measure the immediate and sustained effect of mobile device hydration reminders on urine calcium oxalate supersaturation and urine volume in adolescents with calcium oxalate kidney stones. The candidate brings to this proposal experience as a pediatric urological surgeon at a large urban children's hospital and training in clinical epidemiology. An integral part of his career development will be continued relationship with an outstanding multidisciplinary mentoring team. The candidate's primary mentor is Susan Furth MD, PhD. Dr. Furth is an international expert in treatment adherence among children with chronic kidney disease and has an outstanding track-record of mentorship. Ron Keren MD, MPH, Douglas Wiebe PhD, and Janet Audrain-McGovern PhD, will serve as co-mentors in the areas of clinical trials, ecological momentary assessment of adolescent health, and biobehavioral determinants of adolescent health, respectively. An advisory panel will help guide the candidate's career development and will provide expertise in metabolic kidney stone disease, water access among adolescents, biostatistics, and using mobile games to improve health. The proposed research and training plan will expand the candidate's expertise in advanced statistical analysis, clinical trials, and applying technology to improve health, and will provide the candidate with the skills and experience necessary for a career as a successful independent researcher focused on investigating novel interventions to improve treatment adherence and decrease kidney stone recurrence among adolescents.
The incidence of kidney stones among adolescents is rising and little research has been performed to identify interventions that reduce this population's risk of recurrence. The proposed research will define the temperature thresholds above and below which there is an increased risk of kidney stone presentation among adolescents, identify barriers to water intake among adolescents with kidney stones, and measure the effect of hydration reminders on intermediate outcomes of stone recurrence among adolescents. Taken together, results from this proposal will lead to development of novel interventions to increase water intake among adolescents with nephrolithiasis and will facilitate the candidate's transition to an independent research career in pediatric nephrolithiasis research, with particular expertise in using innovative interventions to increase treatment adherence and decrease kidney stone recurrence among adolescents.
| Ross, Michelle E; Vicedo-Cabrera, Ana M; Kopp, Robert E et al. (2018) Assessment of the combination of temperature and relative humidity on kidney stone presentations. Environ Res 162:97-105 |
| Chu, David I; Tan, Jonathan M; Mattei, Peter et al. (2018) Outcomes of laparoscopic and open surgery in children with and without congenital heart disease. J Pediatr Surg 53:1980-1988 |
| Tasian, Gregory E; Jemielita, Thomas; Goldfarb, David S et al. (2018) Oral Antibiotic Exposure and Kidney Stone Disease. J Am Soc Nephrol 29:1731-1740 |
| Kurtzman, Jane T; Song, Lihai; Ross, Michelle E et al. (2018) Urology Consultation and Emergency Department Revisits for Children with Urinary Stone Disease. J Urol 200:180-186 |
| Tasian, Gregory E (2017) Editorial Comment. J Urol 197:950 |
| Chu, David I; Tan, Jonathan M; Mattei, Peter et al. (2017) Mortality and Morbidity after Laparoscopic Surgery in Children with and without Congenital Heart Disease. J Pediatr 185:88-93.e3 |
| Tasian, Gregory E; Ross, Michelle E; Song, Lihai et al. (2017) Dietary Zinc and Incident Calcium Kidney Stones in Adolescence. J Urol 197:1342-1348 |
| Denburg, Michelle R; Leonard, Mary B; Jemielita, Thomas O et al. (2017) Risk of Urolithiasis in Anorexia Nervosa: A Population-Based Cohort Study Using the Health Improvement Network. Eur Eat Disord Rev 25:406-410 |
| Chu, David I; Zderic, Stephen A; Shukla, Aseem R et al. (2017) The natural history of semen parameters in untreated asymptomatic adolescent varicocele patients: A retrospective cohort study. J Pediatr Urol 13:77.e1-77.e5 |
| Tasian, Gregory E; Kabarriti, Abdo E; Kalmus, Angela et al. (2017) Kidney Stone Recurrence among Children and Adolescents. J Urol 197:246-252 |
Showing the most recent 10 out of 20 publications
