This application proposes a training plan to develop Christopher Girkin, MD into an independent clinician-scientist specializing in investigations of optic nerve structure and visual function. Dr. Girkin is a board certified ophthalmologist with subspecialty training in both neuro-ophthalmology and glaucoma with prior research experience involving the relationship between optic disc structure and visual function in glaucoma. This training program will consist of mentored research, advanced coursework leading to a Masters in Science in Public Health, and multi-disciplinary conferences. Mentored research will be conducted under the direction of a mentorship committee composed of Dr. Cynthia Owsley, Director of the UAB Clinical Research Unit and Dr. Gerald McGwin, Director of the Epidemiology Unit in the UAB Center for Injury Sciences. Dr. David Roth and Dr. Robert Weinreb, Director of the UCSD Glaucoma Service will serve as consultants on the project and as committee members. This research will be conducted through the UAB Optic Nerve Imaging Center that Dr. Girkin has developed over the past two years. Quantitative techniques that evaluate optic disc structure in vivo and specialized visual field tests have been developed to better quantify glaucoma. However, each of these techniques has individual weaknesses and detects different aspects of glaucomatous damage. This project proposes that a composite variable developed from these instruments will better quantify glaucomatous damage. This composite can then be used to determine the measurements or combinations of measurements that best quantify glaucomatous damage defined by confirmatory factor analysis and compare this measurement model in Caucasian and African-American subjects both cross-sectionally and longitudinally.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23EY013959-02
Application #
6622877
Study Section
Special Emphasis Panel (ZEY1-VSN (05))
Program Officer
Everett, Donald F
Project Start
2002-06-01
Project End
2007-05-31
Budget Start
2003-06-01
Budget End
2004-05-31
Support Year
2
Fiscal Year
2003
Total Cost
$199,096
Indirect Cost
Name
University of Alabama Birmingham
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Garg, Aakriti; De Moraes, C Gustavo; Cioffi, George A et al. (2018) Baseline 24-2 Central Visual Field Damage Is Predictive of Global Progressive Field Loss. Am J Ophthalmol 187:92-98
De Moraes, C Gustavo; Hood, Donald C; Thenappan, Abinaya et al. (2017) 24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma. Ophthalmology 124:1449-1456
Skaat, Alon; De Moraes, Carlos Gustavo; Bowd, Christopher et al. (2016) African Descent and Glaucoma Evaluation Study (ADAGES): Racial Differences in Optic Disc Hemorrhage and Beta-Zone Parapapillary Atrophy. Ophthalmology 123:1476-83
Silverman, Anna L; Hammel, Naama; Khachatryan, Naira et al. (2016) Diagnostic Accuracy of the Spectralis and Cirrus Reference Databases in Differentiating between Healthy and Early Glaucoma Eyes. Ophthalmology 123:408-14
Khachatryan, Naira; Medeiros, Felipe A; Sharpsten, Lucie et al. (2015) The African Descent and Glaucoma Evaluation Study (ADAGES): predictors of visual field damage in glaucoma suspects. Am J Ophthalmol 159:777-87
Kuo, Jane Z; Zangwill, Linda M; Medeiros, Felipe A et al. (2015) Quantitative Trait Locus Analysis of SIX1-SIX6 With Retinal Nerve Fiber Layer Thickness in Individuals of European Descent. Am J Ophthalmol 160:123-30.e1
Belghith, Akram; Bowd, Christopher; Weinreb, Robert N et al. (2014) A hierarchical framework for estimating neuroretinal rim area using 3D spectral domain optical coherence tomography (SD-OCT) optic nerve head (ONH) images of healthy and glaucoma eyes. Conf Proc IEEE Eng Med Biol Soc 2014:3869-72
Miki, Atsuya; Medeiros, Felipe A; Weinreb, Robert N et al. (2014) Rates of retinal nerve fiber layer thinning in glaucoma suspect eyes. Ophthalmology 121:1350-8
Belghith, Akram; Bowd, Christopher; Medeiros, Felipe A et al. (2014) Glaucoma progression detection using nonlocal Markov random field prior. J Med Imaging (Bellingham) 1:034504
Belghith, Akram; Balasubramanian, Madhusudhanan; Bowd, Christopher et al. (2014) A unified framework for glaucoma progression detection using Heidelberg Retina Tomograph images. Comput Med Imaging Graph 38:411-20

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