The purpose of this award is to provide support for Dr. Lori Boardman to pursue formal training in the fields of biostatistics, epidemiology and public health, thereby attaining the necessary theoretical and methodological background to further a career in patient- oriented research. The final three years of the award will be devoted to the design, implementation, analysis of data and preparation of the results of a randomized controlled trial of two smoking cessation interventions in a cohort of women referred for the evaluation of abnormal Papanicolaou smears. The primary aims of this study are to evaluate smoking cessation rates between the two groups and to confirm self-reports of cessation through measurement of cervical mucus cotinine. The secondary aims are to determine the regression rate of cervical neoplasia in women who quit smoking compared to those who continue and to assess the independent and combined contribution of human papillomavirus and smoking on the natural history of atypical or low-grade cervical neoplasia (includes cytology and/or histology). This trial will be conducted with the guidance of a multidisciplinary and experienced team including experienced women's health and behavioral health researchers, epidemiologists, an oncologist, and a statistician. Immediate Career Objectives: Pursue formal training in research design and analysis by obtaining a master's degree in public health; Improve abilities to design, perform, analyze and communicate research findings through the preparation of a master's thesis and formal presentations of ongoing research stemming from clinical work in cervical neoplasia; Implement and complete a randomized trial of two smoking cessation interventions in women with cervical neoplasia. Lone-Term Career Objectives: Become an independent and productive investigator in the field of women's health care; Secure independent grant funding for patient-oriented research; Become a leader in academic medicine and mentor more junior investigators interested in women's health.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HD001307-02
Application #
6526963
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Kaufman, Steven
Project Start
2001-09-25
Project End
2006-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
2
Fiscal Year
2002
Total Cost
$123,730
Indirect Cost
Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code
02905
Day, Tania; Weitzen, Sherry; Cooper, Amy S et al. (2008) Should unsatisfactory colposcopy necessitate treatment of cervical intraepithelial neoplasia 1? J Low Genit Tract Dis 12:11-5
Allsworth, Jenifer E; Clarke, Jennifer; Peipert, Jeffrey F et al. (2007) The influence of stress on the menstrual cycle among newly incarcerated women. Womens Health Issues 17:202-9
Fuchs, Karin; Weitzen, Sherry; Wu, Lily et al. (2007) Management of cervical intraepithelial neoplasia 2 in adolescent and young women. J Pediatr Adolesc Gynecol 20:269-74
Boardman, Lori A; Allsworth, Jenifer; Phipps, Maureen G et al. (2006) Risk factors for unintended versus intended rapid repeat pregnancies among adolescents. J Adolesc Health 39:597.e1-8
Boardman, Lori A; Weitzen, Sherry; Stanko, Cara (2006) Atypical squamous cells of undetermined significance, human papillomavirus, and cervical intraepithelial neoplasia 2 or 3 in adolescents: ASC-US, age, and high-grade cervical neoplasia. J Low Genit Tract Dis 10:140-5
Madom, Lindsay M; Boardman, Lori A (2005) HPV testing and cervical cancer screening: recommendations and practice patterns. Med Health R I 88:362-3
Boardman, Lori A; Goldman, Debra L; Cooper, Amy S et al. (2005) CIN in pregnancy: antepartum and postpartum cytology and histology. J Reprod Med 50:13-8
Boardman, Lori A; Stanko, Cara; Weitzen, Sherry et al. (2005) Atypical squamous cells of undetermined significance: human papillomavirus testing in adolescents. Obstet Gynecol 105:741-6
Boardman, Lori A; Steinhoff, Margaret M; Shackelton, Rebecca et al. (2004) A randomized trial of the Fischer cone biopsy excisor and loop electrosurgical excision procedure. Obstet Gynecol 104:745-50
Boardman, Lori A; Cooper, Amy S; Clark, Melissa et al. (2004) HPV, cervical neoplasia and smoking: knowledge among colposcopy patients. J Reprod Med 49:965-72

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