The candidate is an experienced academic clinician, trained in pediatric pulmonology and sleep medicine, who plans to re-train in clinical epidemiology. This award is expected to help transition the candidate's focus from physiological testing to clinical epidemiology. The candidate's career goals are to develop an independent research career concentrating on the identification, diagnosis, treatment, and outcomes assessment of obstructive sleep apnea (OSA) in children. The specific objective of the research proposal is the rigorous systematic assessment (reliability, accuracy, and cost effectiveness) of a diagnostic strategy for OSA in children that relies on clinical predictors and simplified home (unattended) monitoring. The candidate proposes a five-year training program with an experienced team of faculty mentors from strong research departments. This plan describes activities (advanced degree coursework, independent study, patient based clinical research) focused on developing skills in clinical epidemiology with immediate applications to the diagnosis of sleep disordered breathing in children. Specific activities in the plan include research training in statistical methods, experience with data analysis in large databases, supervised experience in preparation of grant proposals for individual research support, and training in the responsible conduct of research. The proposed research addresses important knowledge gaps about diagnostic testing for OSA in children and provides important new data for rational and cost-effective application of technology to an under-recognized health condition of children. Furthermore, clarification of the role of diagnostic testing and outcome assessment in pediatric OSA will be crucial for future randomized controlled trials of treatment efficacy; mechanistic studies, and population based studies of pediatric sleep disorder breathing. Finally, the proposal will provide a key training opportunity to foster the candidate's career development as a clinical epidemiologist with a commitment to patient based research in pediatric sleep medicine and pulmonology.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL004426-02
Application #
6388683
Study Section
Special Emphasis Panel (ZHL1-CSR-F (M1))
Program Officer
Rothgeb, Ann E
Project Start
2000-08-01
Project End
2005-07-31
Budget Start
2001-08-01
Budget End
2002-07-31
Support Year
2
Fiscal Year
2001
Total Cost
$126,630
Indirect Cost
Name
Case Western Reserve University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Moore, Melisa; Kirchner, H Lester; Drotar, Dennis et al. (2011) Correlates of adolescent sleep time and variability in sleep time: the role of individual and health related characteristics. Sleep Med 12:239-45
Archbold, Kristen Hedger; Johnson, Nathan L; Goodwin, James L et al. (2010) Normative heart rate parameters during sleep for children aged 6 to 11 years. J Clin Sleep Med 6:47-50
Anderson, Basil; Storfer-Isser, Amy; Taylor, H Gerry et al. (2009) Associations of executive function with sleepiness and sleep duration in adolescents. Pediatrics 123:e701-7
Moore, Melisa; Kirchner, H Lester; Drotar, Dennis et al. (2009) Relationships among sleepiness, sleep time, and psychological functioning in adolescents. J Pediatr Psychol 34:1175-83
Hibbs, Anna Maria; Johnson, Nathan L; Rosen, Carol L et al. (2008) Prenatal and neonatal risk factors for sleep disordered breathing in school-aged children born preterm. J Pediatr 153:176-82
Ievers-Landis, Carolyn E; Storfer-Isser, Amy; Rosen, Carol et al. (2008) Relationship of sleep parameters, child psychological functioning, and parenting stress to obesity status among preadolescent children. J Dev Behav Pediatr 29:243-52
Johnson, Nathan L; Kirchner, H Lester; Rosen, Carol L et al. (2007) Sleep estimation using wrist actigraphy in adolescents with and without sleep disordered breathing: a comparison of three data modes. Sleep 30:899-905
Redline, Susan; Storfer-Isser, Amy; Rosen, Carol L et al. (2007) Association between metabolic syndrome and sleep-disordered breathing in adolescents. Am J Respir Crit Care Med 176:401-8
Emancipator, Judy L; Storfer-Isser, Amy; Taylor, H Gerry et al. (2006) Variation of cognition and achievement with sleep-disordered breathing in full-term and preterm children. Arch Pediatr Adolesc Med 160:203-10
Spilsbury, James C; Storfer-Isser, Amy; Kirchner, H Lester et al. (2006) Neighborhood disadvantage as a risk factor for pediatric obstructive sleep apnea. J Pediatr 149:342-7

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