The purpose of this K-23 grant proposal is to develop a didactic training and research program that will enable Dr. Adams to become an independent investigator in the epidemiology of cardiovascular disease. Dr. Adams is particularly interested in the epidemiology of cardiovascular disease in survivors of childhood cancer and would like to expand his knowledge and skill in order to look at the precursors of cardiovascular disease in general.
The specific aims of this proposal are: 1) To establish a comprehensive training program in field techniques of epidemiology, follow-up study design and advanced statistical techniques including mathematical model building and survival analysis; 2) To analyze data from an ongoing study at the University of Rochester evaluating cardiovascular functioning in childhood cancer survivors treated with high-dose mediastinal irradiation; 3) To design a non-concurrent prospective study to assess the association between chest irradiation during infancy and coronary artery disease in adulthood; 4) To design and carry out a pilot study to assess the association between chest irradiation during infancy and subclinical cardiovascular disease. This program takes advantage of expertise in preventive cardiology, pediatrics, and radiation-associated heart disease found within the University of Rochester Medical Center. Additionally, a previously well followed cohort in the Rochester area of nearly 2800 individuals exposed to low-dose irradiation to the thymus as infants and 4800 of their siblings provides a unique opportunity to assess the potential association between low-dose chest irradiation during infancy and cardiovascular disease later in life. The major project of this proposal evaluating this cohort is in fact two studies: 1) the follow-up of the entire cohort evaluating the risk of clinical coronary artery disease events associated with radiotherapy and 2) a pilot study clinically evaluating CAD risk factors and cardiac function. At the end of the training program, Dr. Adams will be an independent investigator in the field of preventive cardiology with experience in several study designs. The clinical and public health significance of this proposal is based on the fact that much remains unknown about the epidemiology and pathophysiology of atherosclerosis in special subpopulations such as those exposed to irradiation during childhood. This group of individuals, if shown to be at high risk, constitutes a potentially huge number of persons who may benefit from additional preventive measures.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL070930-02
Application #
6767596
Study Section
Special Emphasis Panel (ZHL1-CSR-J (M1))
Program Officer
Ni, Hanyu
Project Start
2003-07-01
Project End
2008-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
2
Fiscal Year
2004
Total Cost
$121,459
Indirect Cost
Name
University of Rochester
Department
Public Health & Prev Medicine
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Adams, Michael Jacob; Fisher, Susan G; Lipshultz, Steven E et al. (2018) Risk of Coronary Events 55 Years after Thymic Irradiation in the Hempelmann Cohort. Cardiooncology 4:
Lubin, Jay H; Adams, M Jacob; Shore, Roy et al. (2017) Thyroid Cancer Following Childhood Low-Dose Radiation Exposure: A Pooled Analysis of Nine Cohorts. J Clin Endocrinol Metab 102:2575-2583
Adams, Michael Jacob; Grant, Eric J; Kodama, Kazunori et al. (2012) Radiation dose associated with renal failure mortality: a potential pathway to partially explain increased cardiovascular disease mortality observed after whole-body irradiation. Radiat Res 177:220-8
Adams, M Jacob; Dozier, Ann; Shore, Roy E et al. (2010) Breast cancer risk 55+ years after irradiation for an enlarged thymus and its implications for early childhood medical irradiation today. Cancer Epidemiol Biomarkers Prev 19:48-58
Adams, Michael Jacob; Shore, Roy E; Dozier, Ann et al. (2010) Thyroid cancer risk 40+ years after irradiation for an enlarged thymus: an update of the Hempelmann cohort. Radiat Res 174:753-62
Adams, M Jacob; Lipshultz, Steven E (2005) Pathophysiology of anthracycline- and radiation-associated cardiomyopathies: implications for screening and prevention. Pediatr Blood Cancer 44:600-6
Adams, M Jacob; Lipsitz, Stuart R; Colan, Steven D et al. (2004) Cardiovascular status in long-term survivors of Hodgkin's disease treated with chest radiotherapy. J Clin Oncol 22:3139-48