This patient-oriented K23 Career Development Award will provide the candidate with the training and research experience essential to launch an independent research career focused on the early prevention of cardiovascular disease in girls and women. Recent research has identified substantially lower cardiovascular morbidity and mortality in those women able to reach middle age with a constellation of physiologic and behavioral factors known as ideal cardiovascular health. However, little is known about earlier factors that are particularly salient for the maintenance of ideal cardiovascular health into adulthood in general or in women specifically. By using a novel technique of creating sequential risk prediction models in two epidemiologic cohorts with overlapping age ranges, the candidate will quantify the relative importance of cardiovascular health-promoting behavioral, physiologic, and psychological factors during the critical life stages of adolescence and early young adulthood. [The candidate will conduct qualitative studies to identify developmentally appropriate strategies for promotion of behaviors identified in the two cohort studies. The candidate will then be poised to write an R01 application focused on developing and evaluating targeted behavioral interventions for promoting ideal health among adolescent and young adult women from a variety of racial/ethnic backgrounds.] The training plan will support all aspects of the research strategy and uniquely prepare the candidate for an independent research career using longitudinal cohort analyses and qualitative research strategies to inform cutting edge patient-oriented behavioral interventions. The coursework, mentorship team, and research experiences are designed to provide synergistic training in 1) life course and chronic disease epidemiology, 2) statistical methods for studying critical windows in the life course, and 3) [patient-oriented health communications research that informs the design of developmentally appropriate behavioral interventions]. The Harvard School of Public Health, Harvard Graduate School of Education, Harvard Catalyst, and Boston Children's Hospital all offer unparalleled environments in these three areas. The candidate has assembled a mentorship team with expertise in cardiovascular epidemiology, child and adolescent health, longitudinal cohort analysis, focus group methodology, qualitative data analysis, and health communication and health promotion with vulnerable populations. Mentored by this team the candidate will be well-suited to achieve her immediate career goals of furthering her training in patient-oriented research and cardiovascular epidemiology, identifying critical windows in the lives of young women for cardiovascular health maintenance, and translating these findings to cardiovascular health promoting strategies in youth. [Training activities and results will inform submission of R01 proposals to conduct trials of behavioral interventions aimed at the unique needs of adolescent girls and young women and to conduct epidemiologic studies of cardiovascular health promoting factors in early childhood and the peri-natal period.] Ultimately the candidate's goals are to deepen the understanding of factors related to the maintenance of cardiovascular health throughout the life course and to design novel and effective interventions that enhance positive factors and counterbalance negative factors related to cardiovascular disease risk.

Public Health Relevance

Preservation of ideal cardiovascular health across the life course has the potential to reduce morbidity, mortality, and health care costs substantially in the United States. Innovative approaches to the study of longitudinal epidemiologic cohorts are necessary to identify age-specific critical windows and behavioral targets for preservation of cardiovascular health into midlife. The creation of novel risk prediction scores coupled with [qualitative studies of the adolescent and young adult] perspective on cardiovascular health provides a unique opportunity to design targeted patient-oriented interventions with the potential to lead to substantial changes in the long-term health of American women.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23HL122361-04
Application #
9525379
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Ludlam, Shari
Project Start
2015-09-15
Project End
2020-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
4
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Boston Children's Hospital
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
Bucholz, Emily M; Gooding, Holly C; de Ferranti, Sarah D (2018) Awareness of Cardiovascular Risk Factors in U.S. Young Adults Aged 18-39 Years. Am J Prev Med 54:e67-e77
Gooding, Holly C; Ning, Hongyan; Gillman, Matthew W et al. (2017) Application of a Lifestyle-Based Tool to Estimate Premature Cardiovascular Disease Events in Young Adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. JAMA Intern Med 177:1354-1360
Gooding, Holly C; Brown, Courtney A; Wisk, Lauren E (2017) Investing in our future: The importance of ambulatory visits to achieving blood pressure control in young adults. J Clin Hypertens (Greenwich) 19:1298-1300
Unger, Emily S; Kawachi, Ichiro; Milliren, Carly E et al. (2017) Protective Misperception? Prospective Study of Weight Self-Perception and Blood Pressure in Adolescents With Overweight and Obesity. J Adolesc Health 60:680-687
Hausmann, Jonathan S; Touloumtzis, Currie; White, Matthew T et al. (2017) Adolescent and Young Adult Use of Social Media for Health and Its Implications. J Adolesc Health 60:714-719
Gooding, Holly; Johnson, Heather M (2016) The Unchartered Frontier: Preventive Cardiology Between the Ages of 15 and 35 Years. Curr Cardiovasc Risk Rep 10:
Gooding, Holly C; Milliren, Carly; Shay, Christina M et al. (2016) Achieving Cardiovascular Health in Young Adulthood-Which Adolescent Factors Matter? J Adolesc Health 58:119-21
Gooding, Holly C; Sheldrick, R Christopher; Leslie, Laurel K et al. (2016) Adolescent Perceptions of Cholesterol Screening Results: ""Young Invincibles"" or Developing Adults? J Adolesc Health 59:162-70
Sonneville, Kendrin R; Thurston, Idia B; Milliren, Carly E et al. (2016) Weight misperception among young adults with overweight/obesity associated with disordered eating behaviors. Int J Eat Disord 49:937-946
Gooding, Holly C; Shay, Christina M; Ning, Hongyan et al. (2015) Optimal Lifestyle Components in Young Adulthood Are Associated With Maintaining the Ideal Cardiovascular Health Profile Into Middle Age. J Am Heart Assoc 4:

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