Schizophrenia has traditionally been viewed as an illness with prominent clinical features of psychosis and cognitive dysfunction. However, disturbances in emotional processes, including expression, experience and recognition of emotions, also are common areas of dysfunction in patients with schizophrenia. The purpose of this career development award is to examine emotional processes in relation to the course, symptoms and treatment of schizophrenia, and to develop new instruments to assess emotional processes in schizophrenia. The goals for this application can be broadly separated into two groups: longitudinal assessment of emotional processes in schizophrenia, and development of novel emotional probes that will further delineate emotional dysfunction in schizophrenia. The proposed research would assess emotional processes in schizophrenia and to investigate the interrelationship between emotional processes, psychotic symptoms and cognitive dysfunction. Throughout the early part of the project, expression, experience and recognition of emotion would be evaluated with previously established assessments of affective flattening, mood, and ability to discriminate basic emotions. Novel emotional probes that explore emotional processes in a more fundamental manner would then be developed. In the later stages of the project, schizophrenics would be compared with neuropsychiatric controls, and emotional dysfunction would be treated.
| Kohler, Christian G; Walker, Jeffrey B; Martin, Elizabeth A et al. (2010) Facial emotion perception in schizophrenia: a meta-analytic review. Schizophr Bull 36:1009-19 |
| Kohler, Christian G; Loughead, James; Ruparel, Kosha et al. (2008) Brain activation during eye gaze discrimination in stable schizophrenia. Schizophr Res 99:286-93 |
| Kohler, Christian G; Martin, Elizabeth A; Milonova, Marina et al. (2008) Dynamic evoked facial expressions of emotions in schizophrenia. Schizophr Res 105:30-9 |
| Kohler, Christian G; Martin, Elizabeth A; Stolar, Neal et al. (2008) Static posed and evoked facial expressions of emotions in schizophrenia. Schizophr Res 105:49-60 |
| Kohler, Christian G; Barrett, Frederick S; Gur, Ruben C et al. (2007) Association between facial emotion recognition and odor identification in schizophrenia. J Neuropsychiatry Clin Neurosci 19:128-31 |
| Gur, Raquel E; Kohler, Christian G; Ragland, J Daniel et al. (2006) Flat affect in schizophrenia: relation to emotion processing and neurocognitive measures. Schizophr Bull 32:279-87 |
| Calkins, Monica E; Gur, Ruben C; Ragland, J Daniel et al. (2005) Face recognition memory deficits and visual object memory performance in patients with schizophrenia and their relatives. Am J Psychiatry 162:1963-6 |
| Kohler, Christian G; Anselmo-Gallagher, Gerri; Bilker, Warren et al. (2005) Emotion-discrimination deficits in mild Alzheimer disease. Am J Geriatr Psychiatry 13:926-33 |
| Kohler, Christian G; Turner, Travis; Stolar, Neal M et al. (2004) Differences in facial expressions of four universal emotions. Psychiatry Res 128:235-44 |
| Kohler, Christian G; Turner, Travis H; Gur, Raquel E et al. (2004) Recognition of facial emotions in neuropsychiatric disorders. CNS Spectr 9:267-74 |
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