(provided by candidate): This grant application is for the Mentored Patient-Oriented Career Development (K23) Award. The objective of this award is to promote the candidate's long-term goal of conducting clinical trials of psychosocial interventions for adolescents with mood disorders, especially bipolar disorder, and to study the impact of these treatments on adolescent's symptomatic and psychosocial functioning. Developing effective psychosocial treatments for bipolar youth is an important priority. Current treatment guidelines by the American Academy of Child and Adolescent Psychiatry specify that adjunctive psychosocial therapies are almost always indicated in the treatment of bipolar disorder during adolescence. However, at this time, there are no empirically validated psychosocial treatments for bipolar youth. The career development activities described in this application will develop the candidate's knowledge and skills in 1) the diagnosis, psychosocial treatment, and accurate assessment of symptomatic and psychosocial functioning in adolescents with bipolar disorder; 2) the developmental factors that influence the etiology and clinical course of mood disorders during adolescence; 3) strategies to successfully engage mood disordered adolescents in multi-session psychosocial treatments; and 4) the reciprocal relationship between psychosocial factors and symptomatic functioning in bipolar youth. The research study will be comprised of 2 phases. Phase I is designed to integrate developmentally informed psychological, behavioral, and practical strategies into Interpersonal and Social Rhythm Therapy (IPSRT), an empirically supported psychosocial treatment for adults with bipolar disorder, to enhance the treatment of bipolar adolescents. This process will grow from mentored supervision from experts in the field of child/adolescent psychiatry, developmental psychopathology, and clinical intervention research. In addition, the candidate and project therapist will undertake the treatment of 10 pilot cases of bipolar adolescents. The second phase of the research plan consists of a small, preliminary, randomized trial comparing IPSRT-A to treatment as usual in a sample of adolescents with bipolar disorder. Subjects will be assessed at baseline, monthly during treatment, and 6- month follow-up. The skills, training, and pilot data obtained from this award will support the candidate's development of an R01 application in Years 03-05 of the award period.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
1K23MH070570-01A1
Application #
6873342
Study Section
Interventions Research Review Committee (ITV)
Program Officer
Boyce, Cheryl A
Project Start
2005-04-01
Project End
2010-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
1
Fiscal Year
2005
Total Cost
$119,178
Indirect Cost
Name
University of Washington
Department
Psychiatry
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Findling, Robert L; Johnson, Jacqueline L; McClellan, Jon et al. (2010) Double-blind maintenance safety and effectiveness findings from the Treatment of Early-Onset Schizophrenia Spectrum (TEOSS) study. J Am Acad Child Adolesc Psychiatry 49:583-94; quiz 632
Sikich, Linmarie; Frazier, Jean A; McClellan, Jon et al. (2008) Double-blind comparison of first- and second-generation antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the treatment of early-onset schizophrenia spectrum disorders (TEOSS) study. Am J Psychiatry 165:1420-31
Frazier, Jean A; McClellan, Jon; Findling, Robert L et al. (2007) Treatment of early-onset schizophrenia spectrum disorders (TEOSS): demographic and clinical characteristics. J Am Acad Child Adolesc Psychiatry 46:979-88
McClellan, Jon; Sikich, Linmarie; Findling, Robert L et al. (2007) Treatment of early-onset schizophrenia spectrum disorders (TEOSS): rationale, design, and methods. J Am Acad Child Adolesc Psychiatry 46:969-78
Hlastala, Stefanie A; Frank, Ellen (2006) Adapting interpersonal and social rhythm therapy to the developmental needs of adolescents with bipolar disorder. Dev Psychopathol 18:1267-88