(provided by candidate): The proposed Mentored Patient-Oriented Research Career Development Award (K23) is a five-year plan to develop the candidate into an independent researcher in the early identification and treatment of anorexia nervosa (AN). The candidate outlines a training application integrating formal coursework and mentorship from expert investigators in prevention, intervention, eating disorders, and developmental psychopathology that will enable the candidate to: (1) acquire knowledge in child and adolescent development necessary to design developmentally sensitive strategies for case identification and prevention of AN; (2) learn about prevention science and the developmental psychopathology of AN; (3) develop expertise in family functioning and family intervention techniques pertinent to AN families; and (4) obtain advanced skills in the ethics, design, implementation and analysis of randomized clinical trials to test the durability of preventive and early interventions for AN. The primary focus of the research plan will be testing interventions for emerging, clinically significant AN symptoms in children and adolescents. Both acute reduction in extant symptomatology and durability of treatment effects in preventing progression to AN (prophylaxis) over the course of 1.5 years will be examined. The core project will be a controlled clinical trial comparing family treatment (FT) to supportive psychotherapy. The hypothesis is that FT, which has demonstrated efficacy in adolescent AN, will be efficacious earlier in the continuum of prevention and intervention for prodromal AN. Transitions in parenting style will be explored as a mediator of FT, and parental eating pathology as a moderator of FT. The ultimate goal of the proposed program is to prepare the candidate to submit a successful R01 application to test these hypotheses in a larger and sufficiently longitudinal randomized controlled trial.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23MH074506-02
Application #
7117607
Study Section
Special Emphasis Panel (ZMH1-ERB-P (05))
Program Officer
Sherrill, Joel
Project Start
2005-09-01
Project End
2010-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
2
Fiscal Year
2006
Total Cost
$175,668
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Hildebrandt, Tom; Bacow, Terri; Markella, Mariana et al. (2012) Anxiety in anorexia nervosa and its management using family-based treatment. Eur Eat Disord Rev 20:e1-16
Loeb, Katharine L; Lock, James; Grange, Daniel le et al. (2012) Transdiagnostic Theory and Application of Family-Based Treatment for Youth with Eating Disorders. Cogn Behav Pract 19:17-30
Loeb, Katharine L; Le Grange, Daniel; Hildebrandt, Tom et al. (2011) Eating disorders in youth: diagnostic variability and predictive validity. Int J Eat Disord 44:692-702
Loeb, Katharine L; Jones, Jennifer; Roberto, Christina A et al. (2011) Adolescent-adult discrepancies on the eating disorder examination: a function of developmental stage or severity of illness? Int J Eat Disord 44:567-72
Doyle, Peter M; Le Grange, Daniel; Loeb, Katharine et al. (2010) Early response to family-based treatment for adolescent anorexia nervosa. Int J Eat Disord 43:659-62
Loeb, Katharine L; le Grange, Daniel (2009) Family-Based Treatment for Adolescent Eating Disorders: Current Status, New Applications and Future Directions. Int J Child Adolesc health 2:243-254
Loeb, Katharine L; Hirsch, Alicia M; Greif, Rebecca et al. (2009) Family-based treatment of a 17-year-old twin presenting with emerging anorexia nervosa: a case study using the ""Maudsley method"". J Clin Child Adolesc Psychol 38:176-83
Loeb, Katharine L; Walsh, B Timothy; Lock, James et al. (2007) Open trial of family-based treatment for full and partial anorexia nervosa in adolescence: evidence of successful dissemination. J Am Acad Child Adolesc Psychiatry 46:792-800