application): This is an application for a K23-Mentored Patient-Oriented Career Development Award entitled """"""""Face-Name Association: fMRI Studies in Aging & Mild AD"""""""". The primary goal of the proposed research is to utilize fMRI to investigate the functional networks subserving """"""""relational"""""""" explicit memory tasks, such as face-name association, and to examine the alterations in this network that occur in normal aging and mild AD. The ability to learn and remember associations between components of newly acquired information, such as names and faces, is an essential memory requirement of everyday life. Moreover, difficulty recalling proper names is the most common memory complaint of older individuals, raising fears of an underlying neurodegenerative disease, such as Alzheimer s disease (AD). Functional MRI (fMRI) is a powerful new technique for investigating the neural substrates of cognition, and provides an excellent opportunity to study complex memory processes, such as face-name association. It is hypothesized that face-name association will require the integration of multiple brain regions, including the fusiform gyrus, dorsolateral prefrontal cortex and the hippocampal formation, that will be differentially affected by the processes of normal aging and mild AD. An integrated series of cognitive and imaging studies is planned to address the following questions: 1) What is the functional anatomy of memory for face-name associations in young individuals? 2) What functional alterations occur in the brain during these tasks with normal aging? 3) How are the functional changes that occur in mild AD different from those seen in normal aging? 4) Is it feasible to develop fMRI during face-name association tasks as a surrogate marker of response to pharmacologic therapy in AD patients? This functional dissection of the explicit memory network using a clinically relevant task will provide new and important insights about memory alterations that occur with age and in early AD. In order to achieve these goals, the candidate seeks training in 1) fMRI physics and analytic techniques, 2) cognitive neuroscience methodology relevant to explicit memory, and 3) clinical research design and analysis. The proposed research plan, didactic courses, and tutorial instruction from mentors and advisors will serve to foster the candidate's development into an independent clinical researcher in the field of functional neuroimaging and neurodegenerative disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23NS002189-05
Application #
6698547
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Oliver, Eugene J
Project Start
2000-02-01
Project End
2006-01-31
Budget Start
2004-02-01
Budget End
2006-01-31
Support Year
5
Fiscal Year
2004
Total Cost
$159,981
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Ward, Andrew M; Schultz, Aaron P; Huijbers, Willem et al. (2013) The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system. Hum Brain Mapp :
Desikan, Rahul S; McEvoy, Linda K; Thompson, Wesley K et al. (2012) Amyloid-?--associated clinical decline occurs only in the presence of elevated P-tau. Arch Neurol 69:709-13
Rentz, Dorene M; Amariglio, Rebecca E; Becker, J Alex et al. (2011) Face-name associative memory performance is related to amyloid burden in normal elderly. Neuropsychologia 49:2776-83
Pihlajamäki, Maija; O' Keefe, Kelly; Bertram, Lars et al. (2010) Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease. Alzheimer Dis Assoc Disord 24:28-36
Pihlajamäki, Maija; Sperling, Reisa A (2009) Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer's disease and at-risk older individuals. Behav Neurol 21:77-91
Chua, Elizabeth F; Schacter, Daniel L; Sperling, Reisa A (2009) Neural correlates of metamemory: a comparison of feeling-of-knowing and retrospective confidence judgments. J Cogn Neurosci 21:1751-65
Chua, Elizabeth F; Schacter, Daniel L; Sperling, Reisa A (2009) Neural basis for recognition confidence in younger and older adults. Psychol Aging 24:139-53
Dickerson, Bradford C; Sperling, Reisa A (2008) Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies. Neuropsychologia 46:1624-35
Miller, S L; Fenstermacher, E; Bates, J et al. (2008) Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. J Neurol Neurosurg Psychiatry 79:630-5
Dickerson, B C; Miller, S L; Greve, D N et al. (2007) Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study. Hippocampus 17:1060-70

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