We believe that a thorough examination of category-specific recognition and naming abilities in temporal lobe epilepsy (TLE) patients who have been well-studied before and after respective surgery can resolve inconsistencies that exist regarding the neural substrates and organization of category-specific information. Systematic exploration of category-specific functions both pre- and postoperatively with specially designed neurocognitive tests, quantitative volumetric MRI, and intraoperative language assessment will allow us to determine the relationship between TL sites, potential mediating variables (e.g., atypical naming sites, epilepsy duration), and the naming/recognition functions disturbed in patients exhibiting category specific deficits. We have employed Damasio's """"""""mediational/convergence zone"""""""" model of semantic memory as a heuristic framework to generate testable hypotheses for exploring these deficits. Based on this model, one would expect category-specific deficits to routinely occur following TL resections, and preliminary data obtained in our lab support this prediction. These deficits are frequently missed by commonly employed naming measures, despite evidence that they compromise neurocognitive and functional status. Elucidating these constructs will lead to more precise models of semantic memory, and may reveal that some patients undergoing TL resection are at risk for experiencing significant category-specific deficits. Such findings could lead to changes in surgical technique and the selection of surgical candidates, and contribute to improvements in neurocognitive outcome. The PI, who serves as a neuropsychologist/Assistant Professor in the UW Department of Neurology, can draw upon the resources and patient population of a well established epilepsy program. This proposal, if funded, would enable him to develop the necessary skills to mesh his neuropsychological training with advances in neuroimaging and related technologies in an effort to more precisely study brain-behavior relationships, while establishing him as an independent clinician scientist.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Patient-Oriented Research Career Development Award (K23)
Project #
5K23NS049100-02
Application #
7060048
Study Section
NST-2 Subcommittee (NST)
Program Officer
Fureman, Brandy E
Project Start
2005-05-01
Project End
2010-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
2
Fiscal Year
2006
Total Cost
$140,437
Indirect Cost
Name
University of Washington
Department
Neurology
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Gross, Robert E; Stern, Matthew A; Willie, Jon T et al. (2018) Stereotactic laser amygdalohippocampotomy for mesial temporal lobe epilepsy. Ann Neurol 83:575-587
Drane, Daniel L (2018) MRI-Guided stereotactic laser ablation for epilepsy surgery: Promising preliminary results for cognitive outcome. Epilepsy Res 142:170-175
Drane, Daniel L; Loring, David W; Voets, Natalie L et al. (2015) In response: Naming and recognition after laser amygdalohippocampotomy: Is the hippocampus involved? Epilepsia 56:1318-9
Drane, Daniel L; Loring, David W; Voets, Natalie L et al. (2015) Better object recognition and naming outcome with MRI-guided stereotactic laser amygdalohippocampotomy for temporal lobe epilepsy. Epilepsia 56:101-13
James, G Andrew; Tripathi, Shanti Prakash; Ojemann, Jeffrey G et al. (2013) Diminished default mode network recruitment of the hippocampus and parahippocampus in temporal lobe epilepsy. J Neurosurg 119:288-300
Drane, Daniel L; Ojemann, Jeffrey G; Phatak, Vaishali et al. (2013) Famous face identification in temporal lobe epilepsy: support for a multimodal integration model of semantic memory. Cortex 49:1648-67
Drane, Daniel L; Roraback-Carson, Jenny; Hebb, Adam O et al. (2012) Cortical stimulation mapping and Wada results demonstrate a normal variant of right hemisphere language organization. Epilepsia 53:1790-8
Iudicello, Jennifer E; Kellogg, Emily J; Weber, Erica et al. (2012) Semantic cueing improves category verbal fluency in persons living with HIV infection. J Neuropsychiatry Clin Neurosci 24:183-90
Mrazik, Marty; Millis, Scott; Drane, Daniel L (2010) The oral trail making test: effects of age and concurrent validity. Arch Clin Neuropsychol 25:236-43
Drane, Daniel L; Ojemann, George A; Ojemann, Jeffrey G et al. (2009) Category-specific recognition and naming deficits following resection of a right anterior temporal lobe tumor in a patient with atypical language lateralization. Cortex 45:630-40

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