The specific aims of this mid-career patient-oriented research award are: 1) to further establish the candidate's independent patient- oriented clinical research program in neurohumoral mechanisms of aging cardiovascular physiology, and 20 to provide the candidate the time and resources necessary to provide mentorship to trainees pursuing clinical investigation of aging cardiovascular physiology. The candidate has a record of continuously funded productive investigation in patient- oriented research dating from the beginning of this fellowship training in Geriatric Medicine in 1985 to the present. The candidate's patient- oriented research program is funded on the role of the sympathetic nervous system (SNS) and other neurohumoral systems in the regulation of blood pressure and cardiac contractility in normal human aging, and in older patients with hypertension and heart failure. The protected time afforded by this award will permit the candidate to further develop novel methods to assess the regulation of SNS activity, adrenergic receptor function and other neurohumoral mechanisms in older patients with hypertension and heart failure. The candidate has an established record of providing mentorship of pre- and post-doctoral trainees. The candidate's research program will provide the context to permit him to continue training beginning clinical investigators. The candidate's research program and commitment to mentoring will be complemented by the special research and training program strengths of the University of Michigan (UM). These programs include outstanding clinical research facilities in a well-funded General Clinical Research Center, resource provided by several major research centers (e.g. Claude Peppers Geriatrics Center, Institute of Gerontology and Geriatric Research, Education, and Clinical Center at the Ann Arbor VA), and excellent educational resources through the curricula of the UM integrated Geriatric Fellowship Program and the School of Public Health of Science Program in Clinical Research Design and Statistical Analysis. Finally, new initiatives are being developed to facilitate innovative clinical investigation and the training of clinical investigators at the UM (e.g. the Center for Clinical Investigation and the training of clinical investigators at the UM (e.g. the Center for Clinical Investigation and Therapeutics). In summary, the candidate's accomplishment in patient- oriented research, his ability and commitment to mentor clinical investigator trainees, and the research and training strengths of the UM combine to provide an ideal context to accomplish the specific aims of this proposal.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24AG000924-01
Application #
2834625
Study Section
National Institute on Aging Initial Review Group (NIA)
Project Start
1999-05-01
Project End
2004-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Wray, D Walter; Supiano, Mark A (2010) Impact of aldosterone receptor blockade compared with thiazide therapy on sympathetic nervous system function in geriatric hypertension. Hypertension 55:1217-23
Rocchini, Albert P; Yang, John Q; Smith, Marla J et al. (2010) Serial changes in norepinephrine kinetics associated with feeding dogs a high-fat diet. J Clin Hypertens (Greenwich) 12:117-24
Dengel, D R; Brown, M D; Ferrell, R E et al. (2007) A preliminary study on T-786C endothelial nitric oxide synthase gene and renal hemodynamic and blood pressure responses to dietary sodium. Physiol Res 56:393-401
Sengstock, David M; Vaitkevicius, Peter V; Supiano, Mark A (2005) Arterial stiffness is related to insulin resistance in nondiabetic hypertensive older adults. J Clin Endocrinol Metab 90:2823-7
Grekin, Roger J; Ngarmukos, Chardpra-Orn; Williams, David M et al. (2005) Renal norepinephrine spillover during infusion of nonesterified fatty acids. Am J Hypertens 18:422-6
Sengstock, David; Vaitkevicius, Peter V; Supiano, Mark A (2005) Does increased arterial stiffness increase the risk for postural hypotension? Am J Geriatr Cardiol 14:224-9
Glickman, Scott G; Marn, Charles S; Supiano, Mark A et al. (2004) Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity. J Appl Physiol 97:509-14
Grossman, P Michael; Linares, Oscar A; Supiano, Mark A et al. (2004) Cardiac-specific norepinephrine mass transport and its relationship to left ventricular size and systolic performance. Am J Physiol Heart Circ Physiol 287:H878-88
Mehta, Rajendra H; Supiano, Mark A; Oral, Hakan et al. (2003) Compared with control subjects, the systemic sympathetic nervous system is activated in patients with mitral regurgitation. Am Heart J 145:1078-85