This is an application for a K24 Midcareer Investigator Award in patient-oriented research. The candidate is a professor of neurology and epidemiology at the Boston University with an established record as a researcher, clinician, and educator. The proposed mentoring and research plans are focused on two major themes: (1) discovering and quantifying ways of characterizing genetic risk for Alzheimer's disease and (2) creating and evaluating real-world procedures for communicating genetic risk. The Mentoring Plan takes advantage of the candidate's experiences and position as director of a large and diverse program in patient-oriented research with Alzheimer's disease patients and their families. Under the supervision of the K24 awardee, each trainee will develop and carry out independent research projects from design to publication. Trainees will obtain hands-on experience in multiple aspects of patient-oriented research including focus group and survey development, small and large scale clinical trials, and epidemiological studies. Trainees will participate in research seminars, methodology and grant-writing workshops, meetings on multidisciplinary consensus conferences and in the ongoing K30 Clinical Research Curriculum at BU. Funding for statistical consultation will assure that biostatistical support is readily available. Formal coursework at the BU School of Public Health will be encouraged. In all activities, trainees will follow a detailed mentoring plan with a schedule of structured activities, and with clear roles, specific responsibilities and concrete evaluation plans measuring knowledge, skill and productivity. The Research Plan builds upon two large funded R01 projects, the Multi-Institutional Research in Alzheimer's Genetic Epidemiology (MIRAGE) Study and the Risk Evaluation and Education for Alzheimer's Disease (REVEAL) Study. Each of these studies has been competitively renewed at least once, and has extensive ongoing operations and data available for trainee education and analysis of data. This award will also help refine the candidate's own research skills in the area of genetic epidemiology and lay the groundwork for expanding the MIRAGE Study and the REVEAL Study in new directions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
7K24AG027841-06
Application #
8322956
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Miller, Marilyn
Project Start
2006-09-30
Project End
2012-11-30
Budget Start
2012-01-01
Budget End
2012-11-30
Support Year
6
Fiscal Year
2010
Total Cost
$190,185
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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Green, Robert C; Christensen, Kurt D; Cupples, L Adrienne et al. (2015) A randomized noninferiority trial of condensed protocols for genetic risk disclosure of Alzheimer's disease. Alzheimers Dement 11:1222-30
Krier, Joel B; Green, Robert C (2015) Management of Incidental Findings in Clinical Genomic Sequencing. Curr Protoc Hum Genet 87:9.23.1-16
Wang, Li-San; Naj, Adam C; Graham, Robert R et al. (2015) Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol 72:209-16
Lerner, Barbara; Roberts, J Scott; Shwartz, Michael et al. (2014) Distinct communication patterns during genetic counseling for late-onset Alzheimer's risk assessment. Patient Educ Couns 94:170-9
Shen, Li; Thompson, Paul M; Potkin, Steven G et al. (2014) Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers. Brain Imaging Behav 8:183-207
Peterson, David; Munger, Caitlin; Crowley, Jared et al. (2014) Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Alzheimers Dement 10:366-71
Gross, Alden L; Sherva, Richard; Mukherjee, Shubhabrata et al. (2014) Calibrating longitudinal cognition in Alzheimer's disease across diverse test batteries and datasets. Neuroepidemiology 43:194-205
Sparks, Jeffrey A; Iversen, Maura D; Miller Kroouze, Rachel et al. (2014) Personalized Risk Estimator for Rheumatoid Arthritis (PRE-RA) Family Study: rationale and design for a randomized controlled trial evaluating rheumatoid arthritis risk education to first-degree relatives. Contemp Clin Trials 39:145-57
Karlawish, Jason; Green, Robert C (2014) Minding the aging brain: are we ready for personalized medicine? Am J Psychiatry 171:137-9

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