[] Principal tnvestigator/Program Director (Last, first, middle): Gulick, Roy M. DESCRIPTION: State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project+ Describe concisely the research design and methods for achieving these goals. Avoid summaries of past accomplishments and the use of the first person. This abstract is meant to serve as a succinct and accurate description of the proposed work when separated from the application. If the appfication is funded, this description, as is, will become public informa_on. Therefore, do not _nc|ude proprietary_confidential information. DO NOT F.._CEED 'PrtE SPACE PROVIDED, This proposal is to support the candidate, Roy M. Gulick, MD, MPH, Associate Professor of Medicine and the Director of the Cornell HIV Clinical Tdals Unit, as an HIV/AIDS clinical researcher. Dr+ Gulick has conducted clinical trials in H IV-infected patients since 1989, with a focus on antiretroviral therapy studies. His long-term career goals are to design, conduct, and analyze high-quality research to address clinically important questions in the treatment of patients with HIV/AIDS and to teach and mentor trainees to help develop their careers as clinical investigators.
The specific aims of the proposal are: (1): to compare three simple protease inhibitor (PI)-spadng regimens in HIV-infected, treatment-naTve patients: zidovudine/lamivudine with either (a) the non-nucleoside reverse transcriptase inhibitor (NNRTI), efavirenz; (b) the nucleoside reverse transcriptase inhibitor (nRTI), abacavir; or (c) the combination of efavirenz and abacavir; (2) (a) to evaluate and compare the safety, pharmacokinetics, and antiretroviral activity of four dose levels of T-1249, an investigational HIV fusion inhibitor; and (b) to design and implement a pilot study of dual HIV entry inhibitors; (3): to study an HIV gag DNA vaccine in HIV-infected patients with CD4 cell counts >500/mm3 and virologic suppression on a potent antiretroviral regimen; and (4): to assist in the planning, design and conduct of antiretroviral therapy studies in Haiti.
The specific aims will be accomplished by designing, conducting, and analyzing clinical tdals of both antiretroviral therapies and immune-based therapies, and by teaching and mentoring trainees from Weill Medical College of Cornell University and developing a training program for prospective investigators from developing countries, such as Haiti. Clinical trials of novel drugs and strategies will improve the treatment of HIV-infected patients, both in the United States and the developing world. Effective mentodng and training will help develop future clinical investigators. PERFORMANCE SITE ========================================Section End===========================================
Showing the most recent 10 out of 78 publications
