I am a clinical investigator with a research interest in the pathobiology of pulmonary infections. I perform molecular assays on clinical samples obtained by bronchoalveolar lavage and then conduct mechanistic studies in model systems. This approach has been productive and has been effective in training clinical investigators. A recently funded R01-supported study, for which I am a co-PI, is titled """"""""Longitudinal Studies of HIV-Associated Bacterial Pneumonia."""""""" This study extends the work of the laboratory to investigate bacterial pneumonia. The hypothesis of this study is that HIV-positive individuals receiving antiretroviral therapy will continue to develop bacterial pneumonia and other pulmonary infections that will lead to characteristic cellular recruitment and activation in the lung. This process will enhance HIV-1 replication and mutation, accelerating the course of AIDS. The longitudinal study is the subject of the research section of this grant. This project represents an extension of my research approach. The hypothesis will be tested via nested case control analysis of a prospectively assembled cohort with surrogate markers of disease as endpoints. I currently spend 45% effort in clinical service. The K24 Midcareer Investigator Award in Patient-Oriented Research would enable me to reduce patient care responsibilities to 10% effort, so I can increase my focus on training the next generation of clinical investigators. I will be able to increase by 2-fold the number of physicians who I can adequately mentor in translational research. A second goal of the K24 award is to obtain focused training in epidemiology and biostatistics. This didactic experience will enhance my collaboration with biostatisticians and will allow me to learn the quantitative techniques required to analyze large data sets. The K24 will also support a collaboration with Dr. llana Belitskaya-Levy, a biostatistician with expertise in hierarchical clustering and HIV mutational analysis. We will develop novel algorithms to stratify patients and analyze viral evolution over the course of the longitudinal grant. The support provide by the K24 award will enhance my potential to participate in translational research programs that develop effective, novel strategies for the improved care of HIV-infected patients with secondary pulmonary infections.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
3K24AI080298-05S1
Application #
8666385
Study Section
Program Officer
Huebner, Robin E
Project Start
2013-08-15
Project End
2015-08-14
Budget Start
2013-08-15
Budget End
2015-08-14
Support Year
5
Fiscal Year
2013
Total Cost
$103,215
Indirect Cost
$7,646
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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Segal, Leopoldo N; Clemente, Jose C; Li, Yonghua et al. (2017) Anaerobic Bacterial Fermentation Products Increase Tuberculosis Risk in Antiretroviral-Drug-Treated HIV Patients. Cell Host Microbe 21:530-537.e4
Segal, Leopoldo N; Clemente, Jose C; Tsay, Jun-Chieh J et al. (2016) Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. Nat Microbiol 1:16031
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Weiden, Michael D; Hoshino, Satomi; Levy, David N et al. (2014) Adenosine deaminase acting on RNA-1 (ADAR1) inhibits HIV-1 replication in human alveolar macrophages. PLoS One 9:e108476
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Weiden, Michael D; Naveed, Bushra; Kwon, Sophia et al. (2013) Cardiovascular biomarkers predict susceptibility to lung injury in World Trade Center dust-exposed firefighters. Eur Respir J 41:1023-30
Cho, Soo Jung; Nolan, Anna; Echevarria, Ghislaine C et al. (2013) Chitotriosidase is a biomarker for the resistance to World Trade Center lung injury in New York City firefighters. J Clin Immunol 33:1134-42
Webber, Mayris P; Glaser, Michelle S; Weakley, Jessica et al. (2011) Physician-diagnosed respiratory conditions and mental health symptoms 7-9 years following the World Trade Center disaster. Am J Ind Med 54:661-71

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