Todd Brown, MD, PhD, an Associate Professor of Medicine and Endocrinology in the Division of Endocrinology, Diabetes, & Metabolism at Johns Hopkins University, submits this application for a K24 Mid-Career Development award to provide protected time to mentor trainees in patient- oriented research in HIV Endocrinology. Dr. Brown is one of the few endocrinologists worldwide specializing in endocrine and metabolic disorders in HIV-infected patients. He will pursue additional training to hone his mentoring skills in order to build on his established record of mentorship and foster the research careers of early investigators. Candidate: Dr. Brown is a highly productive clinical researcher in the HIV Comorbidities field. Since 2004, he has been continuously NIH-funded to investigate the epidemiology, pathogenesis, and clinical management of endocrine and metabolic dysfunction in HIV-infected persons, using long-standing, NIH-supported infrastructure as a platform for his investigations, including the Multicenter AIDS Cohort Study (MACS), the Women's Interagency HIV Study (WIHS), and the AIDS Clinical Trials Group. With his uncommon skill set and strong POR program in endocrine and metabolic complications in HIV, he has been a sought-after collaborator and mentor at Johns Hopkins and at institutions from around the country. Mentoring Plan/Environment: This application will leverage the extensive training resources at Johns Hopkins, including the Center for AIDS Research, the Institute for Clinical and Translational Research, and T32 training grants in a variety of specialties. It will also draw on the unparallele resources of the MACS and WIHS and other funded studies to serve as a platform for POR trainees at multiple levels. Research Plan: The novel research supported by this K24 award will make a significant contribution to the understanding of the causes and consequences of endocrine and metabolic abnormalities in HIV-infected persons in three major areas: 1) Osteoporosis and Fracture Risk, 2) Hypogonadism, and 3) Insulin Resistance. It will build on ongoing work in the MACS and WIHS, explore new hypotheses, and expand opportunities for trainees.

Public Health Relevance

Todd Brown, MD, PhD is an endocrinologist and epidemiologist at Johns Hopkins University whose primary research and clinical interest over the last 15 years has focused on the causes and consequences of endocrine and metabolic dysfunction in HIV-infected persons. This career development award will provide additional training and protected time for him to mentor trainees interested in patient-oriented research in the HIV Comorbidity field.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AI120834-03
Application #
9300854
Study Section
Acquired Immunodeficiency Syndrome Research Review Committee (AIDS)
Program Officer
Huebner, Robin E
Project Start
2015-07-01
Project End
2020-06-30
Budget Start
2017-07-01
Budget End
2018-06-30
Support Year
3
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Tibuakuu, Martin; Zhao, Di; Saxena, Ankita et al. (2018) Low thigh muscle mass is associated with coronary artery stenosis among HIV-infected and HIV-uninfected men: The Multicenter AIDS Cohort Study (MACS). J Cardiovasc Comput Tomogr 12:131-138
Mellor-Crummey, Lauren E; Lake, Jordan E; Wilhalme, Holly et al. (2018) A Comparison of the Liver Fat Score and CT Liver-to-Spleen Ratio as Predictors of Fatty Liver Disease by HIV Serostatus. J Clin Gastroenterol Hepatol 2:
Kelesidis, Theodoros; Moser, Carlee B; Johnston, Elizabeth et al. (2018) Brief Report: Changes in Plasma RANKL-Osteoprotegerin in a Prospective, Randomized Clinical Trial of Initial Antiviral Therapy: A5260s. J Acquir Immune Defic Syndr 78:362-366
Erlandson, Kristine M; Lake, Jordan E; Sim, Myung et al. (2018) Bone Mineral Density Declines Twice as Quickly Among HIV-Infected Women Compared With Men. J Acquir Immune Defic Syndr 77:288-294
Lake, Jordan E; Li, Xiuhong; Palella Jr, Frank J et al. (2018) Metabolic health across the BMI spectrum in HIV-infected and HIV-uninfected men. AIDS 32:49-57
Erlandson, Kristine M; MaWhinney, Samantha; Wilson, Melissa et al. (2018) Physical function improvements with moderate or high-intensity exercise among older adults with or without HIV infection. AIDS 32:2317-2326
Hawkins, Kellie L; Zhang, Long; Ng, Derek K et al. (2018) Abdominal obesity, sarcopenia, and osteoporosis are associated with frailty in men living with and without HIV. AIDS 32:1257-1266
Kelesidis, Theodoros; Tran, Thuy Tien T; Brown, Todd T et al. (2017) Changes in plasma levels of oxidized lipoproteins and lipoprotein subfractions with atazanavir-, raltegravir-, darunavir-based initial antiviral therapy and associations with common carotid artery intima-media thickness: ACTG 5260s. Antivir Ther 22:113-126
Erlandson, Kristine M; Fiorillo, Suzanne; Masawi, Fadzai et al. (2017) Antiretroviral initiation is associated with increased skeletal muscle area and fat content. AIDS 31:1831-1838
Hawkins, Kellie L; Brown, Todd T; Margolick, Joseph B et al. (2017) Geriatric syndromes: new frontiers in HIV and sarcopenia. AIDS 31 Suppl 2:S137-S146

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