Dr. Lindsey Ann Criswell has demonstrated a strong commitment to patient-oriented research since the beginning of her rheumatology fellowship training at the University of California, San Francisco (UCSF). Dr. Criswell's track record in peer-reviewed publications and her ability to successfully compete for NIH and other sources of research funding provide compelling evidence of her ability to conduct high quality patient-oriented research. Furthermore, Dr. Criswell has successfully mentored a large number of junior clinical investigators who are now establishing their own independent patient-oriented research programs. During the past six years, Dr. Criswell's research program has focused on the genetic epidemiology of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This work has led to several important findings, including the association of tumor necrosis factor polymorphism with RA severity through an interaction with the HLA-DRB 1 shared epitope. Due to the rapid pace of advances in analytic methods for genetically complex diseases such as RA and SLE, Dr. Criswell must continue to devote a substantial amount of time and effort to mastering these rapidly evolving methods. The K24 award offers a unique opportunity to provide support for this essential ongoing training. Dr. Criswell's immediate research goals are to successfully complete the research that is now funded and underway within her research unit. This application describes 3 projects that utilize state of the art methods to identify genetic and non-genetic risk factors for these complex diseases. The expertise of the study investigators in the areas of rheumatology, genetics and statistics, in conjunction with the progress of these studies to date, ensures a high likelihood of success for this work. The research environment at UCSF provides an outstanding environment in which Dr. Criswell can continue to develop as a leader in patient-oriented clinical research and as a mentor to junior clinical investigators. As a result of Dr. Criswell's role as the Associate Director of the UCSF General Clinical Research Center (GCRC), she is ideally positioned to make a major impact at UCSF as a mentor for young clinical investigators. Dr. Criswell has precisely the skills and career goals for which this program was developed, and the resources of the K24 award would greatly enhance Dr. Criswell's ability to accomplish her goals as a patient-oriented clinical researcher and mentor through the provision of essential resources and relief of patient care and other activities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AR002175-05
Application #
6898460
Study Section
Special Emphasis Panel (ZAR1-TAS-A (J1))
Program Officer
Gretz, Elizabeth
Project Start
2001-09-27
Project End
2007-05-31
Budget Start
2005-06-01
Budget End
2007-05-31
Support Year
5
Fiscal Year
2005
Total Cost
$125,952
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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Mok, Amanda; Solomon, Olivia; Nayak, Renuka R et al. (2016) Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses. Lupus Sci Med 3:e000183
Chung, Sharon A; Nititham, Joanne; Elboudwarej, Emon et al. (2015) Genome-Wide Assessment of Differential DNA Methylation Associated with Autoantibody Production in Systemic Lupus Erythematosus. PLoS One 10:e0129813
Morris, D L; Fernando, M M A; Taylor, K E et al. (2014) MHC associations with clinical and autoantibody manifestations in European SLE. Genes Immun 15:210-7
Kaiser, Rachel; Tang, Ling Fung; Taylor, Kimberly E et al. (2014) A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosus. Arthritis Rheumatol 66:1882-7
Chung, Sharon A; Brown, Elizabeth E; Williams, Adrienne H et al. (2014) Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. J Am Soc Nephrol 25:2859-70
Freedman, Barry I; Langefeld, Carl D; Andringa, Kelly K et al. (2014) End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheumatol 66:390-6
Kaiser, Rachel; Taylor, Kimberly E; Deng, Yun et al. (2013) Brief Report: Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians. Arthritis Rheum 65:211-5
Wang, Chuan; Ahlford, Annika; Järvinen, Tiina M et al. (2013) Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations. Eur J Hum Genet 21:994-9
Ramos, Paula S; Oates, James C; Kamen, Diane L et al. (2013) Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry. J Rheumatol 40:842-9

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