Osteoporosis is a significant concern for both older men and women. Recent studies suggest skeletal biomarkers might provide important information about the biologic causes of osteoporosis and may be useful to predict fracture alone or when combined with other risk factors. To extend his ongoing NIH-funded work on biomarkers and skeletal fragility, Dr. Douglas Bauer, Professor of Medicine, Epidemiology & Biostatistics at the University of California, San Francisco, is requesting a renewal of his K24 Midcareer Investigator Award in Patient-Oriented Research with the scientific goals of developing new and clinically useful proteomic biomarkers using data from a well characterized longitudinal cohort of older men (MrOS). Taking advantage of ongoing assessments for fracture and recent funding for proteomic measurements in serum collected at baseline, this study will explore the prospective relationship between proteomic profile and incident vertebral fracture in 3000 MrOS participants. Using these and other data from multiple large studies available through his longstanding affiliation with the San Francisco Coordinating Center, Dr. Bauer will continue to mentor young investigators who are interested in clinical research, particularly residents. With the initial K24 award Dr. Bauer mentored residents and fellows who are now pursuing additional research training and academic careers. In conjunction with the UCSF Clinical and Translational Science Institute, during the initial K24 award he also developed and directed a new comprehensive Resident Research Program. The goal of this novel program is to promote clinical research careers by providing residents with formal instruction in research methods, pilot funding and opportunities to participate in mentored research projects. The continuation of this K24 award is critical to protect Dr. Bauer's time and allow him to continue to make significant contributions towards patient-oriented research related to biomarkers and skeletal fragility and to expand his successful mentoring program.

Public Health Relevance

Osteoporotic fractures are an important public health concern. This project will build on previous work by the applicant to understand the biologic factors associated with osteoporotic fractures, particularly in men. The project will also allow the application to continue and expand his successful mentoring program for junior investigators who are interested in patient-oriented research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24AR051895-10
Application #
8883376
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Program Officer
Alekel, D Lee
Project Start
2005-07-01
Project End
2017-03-31
Budget Start
2015-04-01
Budget End
2017-03-31
Support Year
10
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Bauer, Douglas C; Black, Dennis M; Bouxsein, Mary L et al. (2018) Treatment-Related Changes in Bone Turnover and Fracture Risk Reduction in Clinical Trials of Anti-Resorptive Drugs: A Meta-Regression. J Bone Miner Res 33:634-642
Chaffee, Benjamin W; Couch, Elizabeth T; Gansky, Stuart A (2018) Adolescents' smokeless tobacco susceptibility by perceived professional baseball players' use. J Public Health Dent 78:5-8
Moazed, Farzad; Hendrickson, Carolyn; Nelson, Mary et al. (2018) Platelet aggregation after blunt trauma is associated with the acute respiratory distress syndrome and altered by cigarette smoke exposure. J Trauma Acute Care Surg 84:365-371
Segna, D; Bauer, D C; Feller, M et al. (2018) Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts. J Intern Med 283:56-72
Moazed, Farzad; Calfee, Carolyn S (2017) The Canary in the Coal Mine Is Coughing: Electronic Cigarettes and Respiratory Symptoms in Adolescents. Am J Respir Crit Care Med 195:974-976
Park, Linda G; Dracup, Kathleen; Whooley, Mary A et al. (2017) Symptom Diary Use and Improved Survival for Patients With Heart Failure. Circ Heart Fail 10:
Chaffee, Benjamin W; Urata, Janelle; Couch, Elizabeth T et al. (2017) Perceived Flavored Smokeless Tobacco Ease-of-use and Youth Susceptibility. Tob Regul Sci 3:367-373
Nielson, Carrie M; Wiedrick, Jack; Shen, Jian et al. (2017) Identification of Hip BMD Loss and Fracture Risk Markers Through Population-Based Serum Proteomics. J Bone Miner Res 32:1559-1567
Park, Linda G; Schopfer, David W; Zhang, Ning et al. (2017) Participation in Cardiac Rehabilitation Among Patients With Heart Failure. J Card Fail 23:427-431
Borges, Tássia Silvana; Chaffee, Benjamin W; Kramer, Paulo Floriani et al. (2017) Relationship between overweight/obesity in the first year of age and traumatic dental injuries in early childhood: Findings from a birth cohort study. Dent Traumatol 33:465-471

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