Abstract

This proposal is for a competitive renewal of a K24 Award from the NIDA. K24 support has been pivotal in Dr. Moore developing a program of patient-oriented research and training focused on HIV-infected patients with a history of drug abuse. The core of his program is a longitudinal cohort of HIV-infected patients receiving care. Injecting drug use (IDU) is the risk factor for HIV transmission in over half of the cohort, and active drug use is common. In the past 5 years, Dr. Moore and investigators he mentors have shown that IDU is associated with significant lower rates of HIV viral suppression, immunologic response, and an increase by 50% in the relative incidence of AIDS-defining illness in IDUs compared to non-IDUs. Active drug use is a particular barrier to HIV response, yet even short-term abstinence is associated with a significant improvement in outcomes. A relative decline in the benefit of HAART in drug users has important implications for the management of HIV infection since IDU transmission accounts for about 25% of HIV cases in the U.S., and 3-4 million HIV-infected persons worldwide. The cohort now has over 21,000 person-years of follow-up time;The proposed research will focus on long-term treatment and outcomes of HIV-infection in IDUs, and on co-morbidity such as hepatitis C. In addition, new collaborative efforts will provide new resources for research and mentoring. These include a new HIV primary care clinic on-site within a substance abuse treatment facility where intervention strategies to improve care and outcomes are being assessed;A longitudinal cohort from a multisite U.S. network of HIV providers will provide opportunities to assess the generalizability of our findings and expand the scope of our research;and a collaboration with the AIDS Link to lntravenous Experiences (ALIVE) cohort that will provide comparisons to HIV-infected drugs users who are not in care and HIV seronegative drug users. Renewal of the K24 Award will support continued research productivity and mentoring to improve care of the HIV-infected IDU.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24DA000432-10
Application #
7676679
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Lambert, Elizabeth
Project Start
2000-09-25
Project End
2012-08-31
Budget Start
2009-09-01
Budget End
2012-08-31
Support Year
10
Fiscal Year
2009
Total Cost
$176,103
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Elion, Richard A; Althoff, Keri N; Zhang, Jinbing et al. (2018) Recent Abacavir Use Increases Risk of Type 1 and Type 2 Myocardial Infarctions Among Adults With HIV. J Acquir Immune Defic Syndr 78:62-72
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
Yanik, Elizabeth L; Hernández-Ramírez, Raúl U; Qin, Li et al. (2018) Brief Report: Cutaneous Melanoma Risk Among People With HIV in the United States and Canada. J Acquir Immune Defic Syndr 78:499-504
Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40
Dubrow, Robert; Qin, Li; Lin, Haiqun et al. (2017) Association of CD4+ T-cell Count, HIV-1 RNA Viral Load, and Antiretroviral Therapy With Kaposi Sarcoma Risk Among HIV-infected Persons in the United States and Canada. J Acquir Immune Defic Syndr 75:382-390
Muzaale, A D; Althoff, K N; Sperati, C J et al. (2017) Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors. Am J Transplant 17:1823-1832
Buchacz, Kate; Lau, Bryan; Jing, Yuezhou et al. (2016) Incidence of AIDS-Defining Opportunistic Infections in a Multicohort Analysis of HIV-infected Persons in the United States and Canada, 2000-2010. J Infect Dis 214:862-72
Pettit, April C; Mendes, Adell; Jenkins, Cathy et al. (2016) Timing of Antiretroviral Treatment, Immunovirologic Status, and TB Risk: Implications for Testing and Treatment. J Acquir Immune Defic Syndr 72:572-8

Showing the most recent 10 out of 142 publications