? Obesity is a serious and growing public health problem in this country and around the world. There is a continuing need for investigators with the knowledge of and experience with a range of physiological and behavioral methods to translate new information from studies in animals into new insights in humans through the performance of controlled studies in human subjects. This application is designed in a small way to address this need. The applicant is a mid-career investigator with experience in both animal and human studies in the areas of dietary fat metabolism, insulin resistance, and body weight regulation who is requesting 5 more years of support to 1. continue physiological studies in human subjects conducted in the over and underfed conditions to explore how the body senses nutrient balance and how biological/behavioral responses to positive and/or negative energy balance relate to weight gain. 2. To use his experience in patient oriented research (POR) to continue to mentor junior investigators in their studies of lipid metabolism, insulin resistance, hunger/satiety, exercise, weight gain/loss and related areas. 3. To facilitate interactions and experimental collaborations between established basic researchers working primarily in vitro with junior investigators performing physiological studies in human subjects. 4. To continue to devote some administrative time to activities that promote the professional development of junior investigators and provide the opportunity for these individuals to consider a career in POR. During the previous period of support the applicant was awarded a new RO1 that is supporting a prospective longitudinal cohort study of thin and obesity prone individuals to see if physiological and behavioral responses to short term overfeeding predict subsequent weight gain. In addition, 6 of the 11 post-doctoral fellows that he has worked with during the period of support have received K awards and 2 have received individual NRSA awards. Two junior investigators that he has mentored have received individual RO1 awards and the company that he provides technical support for received an SBIR. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
2K24DK002935-06
Application #
7097158
Study Section
Special Emphasis Panel (ZDK1-GRB-4 (J2))
Program Officer
Podskalny, Judith M,
Project Start
2001-05-01
Project End
2011-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
6
Fiscal Year
2006
Total Cost
$175,578
Indirect Cost
Name
Denver Health and Hospital Authority
Department
Type
DUNS #
093564180
City
Denver
State
CO
Country
United States
Zip Code
80204
Creasy, Seth A; Rynders, Corey A; Bergouignan, Audrey et al. (2018) Free-Living Responses in Energy Balance to Short-Term Overfeeding in Adults Differing in Propensity for Obesity. Obesity (Silver Spring) 26:696-702
Rynders, Corey A; Bergouignan, Audrey; Kealey, Elizabeth et al. (2017) Ability to adjust nocturnal fat oxidation in response to overfeeding predicts 5-year weight gain in adults. Obesity (Silver Spring) 25:873-880
Pereira, Rocio I; Low Wang, Cecilia C; Wolfe, Pamela et al. (2016) Associations of Adiponectin with Adiposity, Insulin Sensitivity, and Diet in Young, Healthy, Mexican Americans and Non-Latino White Adults. Int J Environ Res Public Health 13:ijerph13010054
Hernandez, Teri L; Bessesen, Daniel H; Cox-York, Kimberly A et al. (2015) Femoral lipectomy increases postprandial lipemia in women. Am J Physiol Endocrinol Metab 309:E63-71
Bessesen, Daniel H; Cox-York, Kimberly A; Hernandez, Teri Lynn et al. (2015) Postprandial triglycerides and adipose tissue storage of dietary fatty acids: impact of menopause and estradiol. Obesity (Silver Spring) 23:145-53
Schmidt, Stacy L; Bessesen, Daniel H; Stotz, Sarah et al. (2014) Adrenergic control of lipolysis in women compared with men. J Appl Physiol (1985) 117:1008-19
Bergouignan, Audrey; Kealey, Elizabeth H; Schmidt, Stacy L et al. (2014) Twenty-four hour total and dietary fat oxidation in lean, obese and reduced-obese adults with and without a bout of exercise. PLoS One 9:e94181
Schmidt, S L; Kealey, E H; Horton, T J et al. (2013) The effects of short-term overfeeding on energy expenditure and nutrient oxidation in obesity-prone and obesity-resistant individuals. Int J Obes (Lond) 37:1192-7
Schmidt, Stacy L; Harmon, Kristin A; Sharp, Teresa A et al. (2012) The effects of overfeeding on spontaneous physical activity in obesity prone and obesity resistant humans. Obesity (Silver Spring) 20:2186-93
Harmon, Kristin A; Gerard, Lori; Jensen, Dalan R et al. (2011) Continuous glucose profiles in obese and normal-weight pregnant women on a controlled diet: metabolic determinants of fetal growth. Diabetes Care 34:2198-204

Showing the most recent 10 out of 22 publications