This is an application for a Mid-Career Investigator Award in Patient-Oriented Research (K24) for Viola Vaccarino, MD, PhD. The overall objective is to foster Dr. Vaccarino's academic career and that of new investigators working with her in patient-oriented research involving mind-body relationships in cardiovascular disease. The PI seeks protected time to continue ongoing projects, carry out novel research projects, and mentor junior investigators in this area. The PI has had a long-standing interest in the relationship between psychological/behavioral factors, in particular depression, and the incidence or prognosis of CVD. Recently her research focus has shifted towards a more direct investigation of the pathophysiological mechanisms that mediate these associations in the early phases of coronary heart disease in humans, including the autonomic nervous system, neuro-hormonal factors, inflammation, oxidative stress, and gene-environment interactions. The PI has a growing program in this area. However, she needs protected time to expand her research by obtaining new research grants in this area. An important goal of Dr. Vaccarino's career development is to enhance her mentorship activities and ultimately establish a strong training program to foster the next generation of patient-oriented researchers in this area. Dr. Vaccarino has already been quite successful in attracting new investigators to this area of research and in guiding them towards obtaining independent funding. A number of training programs available at Emory represent a source of capable junior investigators. Dr. Vaccarino seeks protected time to continue her mentorship activities and expand them to attract a larger number of beginning investigators. She also plans to apply for a T32 training grant to develop a formal educational program in clinical/epidemiological research as it applies to cardiovascular diseases. Such a program is currently non-existent at Emory. Dr. Vaccarino's long-term goal is to establish a strong research and training patient-oriented research program at Emory focusing on mind-body interactions on cardiovascular disease. Such a program will draw collaborators from multiple departments and disciplines, will foster the training and career development of new investigators, will draw the recruitment of new faculty with interest in this area and will ultimately contribute enormously to the advancement of this field.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24HL077506-03
Application #
7111714
Study Section
Special Emphasis Panel (ZHL1-CSR-J (M1))
Program Officer
Jobe, Jared B
Project Start
2004-09-01
Project End
2009-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
3
Fiscal Year
2006
Total Cost
$109,395
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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Vaccarino, Viola; Sullivan, Samaah; Hammadah, Muhammad et al. (2018) Mental Stress-Induced-Myocardial Ischemia in Young Patients With Recent Myocardial Infarction: Sex Differences and Mechanisms. Circulation 137:794-805
Pimple, Pratik; Hammadah, Muhammad; Wilmot, Kobina et al. (2018) Chest Pain and Mental Stress-Induced Myocardial Ischemia: Sex Differences. Am J Med 131:540-547.e1
Sullivan, Samaah; Hammadah, Muhammad; Al Mheid, Ibhar et al. (2018) Sex Differences in Hemodynamic and Microvascular Mechanisms of Myocardial Ischemia Induced by Mental Stress. Arterioscler Thromb Vasc Biol 38:473-480
Bremner, J Douglas; Campanella, Carolina; Khan, Zehra et al. (2018) Brain Correlates of Mental Stress-Induced Myocardial Ischemia. Psychosom Med 80:515-525
Hammadah, Muhammad; Al Mheid, Ibhar; Wilmot, Kobina et al. (2018) Association Between High-Sensitivity Cardiac Troponin Levels and Myocardial Ischemia During Mental Stress and Conventional Stress. JACC Cardiovasc Imaging 11:603-611
Sullivan, Samaah; Kelli, Heval M; Hammadah, Muhammad et al. (2018) Neighborhood poverty and hemodynamic, neuroendocrine, and immune response to acute stress among patients with coronary artery disease. Psychoneuroendocrinology 100:145-155
Huang, Yunfeng; Hui, Qin; Walker, Douglas I et al. (2018) Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation. Epigenomics 10:379-393
Bremner, James Douglas; Mishra, Sanskriti; Campanella, Carolina et al. (2017) A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Str Front Psychiatry 8:157
Hammadah, Muhammad; Al Mheid, Ibhar; Wilmot, Kobina et al. (2017) The Mental Stress Ischemia Prognosis Study: Objectives, Study Design, and Prevalence of Inducible Ischemia. Psychosom Med 79:311-317

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