The scientific goal of this project is to investigate the role of relative growth hormone (GH) deficiency in the etiopathology of bone loss in obese men and women, and the mechanisms by which GH may affect bone microarchitecture and strength. The candidate is an Associate Professor of Medicine at Harvard Medical School and a faculty member at Massachusetts General Hospital who is deeply committed to and highly qualified for a career in patient-oriented research and to mentor new clinician investigators. She has an outstanding record of patient-oriented research (POR) and mentoring during the first K24 grant period. The career development goal of this K24 competitive renewal application is to support the candidate's continued professional development as a POR mentor of fellows and junior faculty with her long-term goal of developing independent POR researchers. The candidate's specific short-term mentoring objectives are: 1) to attract and train new trainees, 2) assist her current mentees to obtain K and R grant funding, to develop their own POR focuses and assist with all other aspects of transitioning to independent careers focused on POR, 3) acquire additional mentoring skills and 3) continue and expand teaching in courses that reach a large number of trainees interested in pursuing POR careers. The candidate's NIH grants will form the basis of research project support for trainees. The candidate has a record of leadership in mentoring on a national level and a successful track record of mentoring trainees in the Massachusetts General Hospital (MGH) Endocrine Fellowship program and trainees from a number of other departments. The institutional environment is outstanding at the MGH and Harvard Medical School, with an extremely strong Department of Medicine, a Clinical Translational Science Center grant through Harvard Medical School, and a Clinical Research Program at the MGH, all of which offer a myriad of didactic opportunities, facilities and support. The Department of Medicine has made a strong commitment to the candidate, including protected time and dedicated space. The Midcareer Investigator Award in Patient-Oriented Research is an ideal mechanism to ensure the necessary support to protect time for mentorship for this outstanding mentor, who otherwise would have to increase her clinical and administrative responsibilities, and to ensure the candidate's continued success as a mentor and clinical researcher.
Bone loss is a previously unrecognized but important complication of the obesity epidemic. Growth hormone is important for maintenance of bone health, and blood levels are markedly decreased in individuals with obesity. In this proposal, we seek to understand whether low growth hormone contributes to the bone loss observed in obesity and, if so, specifically how it affects the skeleton.
| Dichtel, Laura E; Lawson, Elizabeth A; Schorr, Melanie et al. (2018) Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum. Neuropsychopharmacology 43:1436-1444 |
| Singhal, Vibha; Tulsiani, Shreya; Campoverde, Karen Joanie et al. (2018) Impaired bone strength estimates at the distal tibia and its determinants in adolescents with anorexia nervosa. Bone 106:61-68 |
| Schorr, Melanie; Dichtel, Laura E; Gerweck, Anu V et al. (2018) Sex differences in body composition and association with cardiometabolic risk. Biol Sex Differ 9:28 |
| Bove, Riley; Healy, Brain C; Musallam, Alexander et al. (2018) Fatty acid binding protein-4 is associated with disability in multiple sclerosis patients. Mult Scler :1352458517750768 |
| Dichtel, Laura E; Bjerre, Mette; Schorr, Melanie et al. (2018) The effect of growth hormone on bioactive IGF in overweight/obese women. Growth Horm IGF Res 40:20-27 |
| Schmelkin, Cindy; Plessow, Franziska; Thomas, Jennifer J et al. (2017) Low oxytocin levels are related to alexithymia in anorexia nervosa. Int J Eat Disord 50:1332-1338 |
| Schorr, Melanie; Marengi, Dean A; Pulumo, Reitumetse L et al. (2017) Oxytocin and Its Relationship to Body Composition, Bone Mineral Density, and Hip Geometry Across the Weight Spectrum. J Clin Endocrinol Metab 102:2814-2824 |
| Tabari, Azadeh; Torriani, Martin; Miller, Karen K et al. (2017) Anorexia Nervosa: Analysis of Trabecular Texture with CT. Radiology 283:178-185 |
| Dichtel, Laura E; Schorr, Melanie; Gill, Corey M et al. (2017) Body composition in pituitary, adrenal and iatrogenic Cushing's syndrome and effects of DHEAS levels. Clin Endocrinol (Oxf) 86:160-162 |
| Bachmann, Katherine N; Schorr, Melanie; Bruno, Alexander G et al. (2017) Vertebral Volumetric Bone Density and Strength Are Impaired in Women With Low-Weight and Atypical Anorexia Nervosa. J Clin Endocrinol Metab 102:57-68 |
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