The applicant Udo Hoffmann MD MPH is a Professor of Radiology at Harvard Medical School and the Chief of the Division for Cardiovascular Imaging in the Department of Radiology at MGH. Dr. Hoffmann has established a patient oriented research (POR) program that combines innovative translational, clinical, and outcomes research methods to demonstrate the value of advanced cardiovascular imaging. Dr. Hoffmann has published approximately 380 peer reviewed papers, among them many in premier medical journals and has received continued independent, peer-reviewed POR NIH funding since 2005. He is among the very few faculty members at Harvard Medical School who are both the PI and Director of a highly successful NHLBI funded T- 32 program (Cardiac MR and CT Research) and a recipient of a K24. Dr. Hoffmann has successfully mentored more than 60 clinical investigators, most of which currently hold faculty positions in major academic centers and actively perform POR. Moreover, Dr. Hoffmann has successfully accomplished all mentoring and scientific goals of the first K24 award period. Overall, these achievements document Dr. Hoffmann's long standing passion and commitment to POR. His excellent publication, funding, and mentoring record together with his current and planned research support provide an excellent foundation to accomplish the aims of this competitive renewal of the K24 Award ?Cardiovascular Imaging in Ischemic Heart Disease?. Dr. Hoffmann proposes a mentoring and research plan that utilizes the synergies of past, ongoing, and future highly innovative independent research projects with educational and training opportunities offered by the cardiac MR CT PET Program, the T32 training program in cardiovascular imaging, the Harvard CTSA, and the Harvard School of Public Health.
The specific aims addressing the charge of the K24 Award are to enable Dr. Hoffmann to: 1) dedicate 25% of his time to mentor clinical investigators based on NIH or equivalent funded projects in ?Cardiovascular Imaging in Ischemic Heart Disease?, 2) to mentor junior and mid-career clinical investigators with the goal to develop them into clinical researchers who can successfully compete for peer reviewed grants, and 3) to continue to expand a POR program that combines translational, clinical, and outcomes research to develop future leaders in clinical research in cardiovascular imaging and beyond. The research plan encompasses four specific aims: 1) To determine the effects of statin treatment on coronary atherosclerosis in HIV patients in 800 patients with HIV randomized to statin therapy vs. placebo, 2) To determine whether high risk coronary plaque predicts cardiovascular events in 4600 patients with clinical suspicion of CAD, 3) To determine the cost effectiveness of CT FFR in patients with stable and acute chest pain, and 4) To use Radiomics to identify novel imaging markers predicting cardiovascular events in participants of the Framingham Heart Study.

Public Health Relevance

This research takes advantage of a rich body of independent funded research in ?Cardiovascular Imaging in Ischemic Heart Disease?. It will permit Dr. Hoffmann to dedicate 25% of his time to mentor junior clinical investigators from the T32 program and the pool of residents, fellows, and junior faculty in Cardiology and Radiology with the goal to develop them into clinical researchers who can successfully compete for peer reviewed grants. In addition, it will allow to expand a patient orientated research program that combines innovative translational, clinical, and outcomes research in cardiovascular imaging and that provides an ideal environment to develop future leaders in clinical research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24HL113128-07
Application #
9475268
Study Section
NHLBI Mentored Patient-Oriented Research Review Committee (MPOR)
Program Officer
Huang, Li-Shin
Project Start
2012-07-01
Project End
2022-04-30
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
7
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
Mahmood, Syed S; Fradley, Michael G; Cohen, Justine V et al. (2018) Myocarditis in Patients Treated With Immune Checkpoint Inhibitors. J Am Coll Cardiol 71:1755-1764
Scholtz, Jan-Erik; Addison, Daniel; Bittner, Daniel O et al. (2018) Diagnostic Performance of Coronary CTA in Intermediate-to-High-Risk Patients for Suspected Acute Coronary Syndrome: Results From an Emergency Department Registry. JACC Cardiovasc Imaging 11:1369-1371
Ferencik, Maros; Hoffmann, Udo (2018) High-Risk Coronary Plaque on Computed Tomography Angiography: Time to Recognize a New Imaging Risk Factor. Circ Cardiovasc Imaging 11:e007288
Puchner, Stefan B; Mayrhofer, Thomas; Park, Jakob et al. (2018) Differences in the association of total versus local coronary artery calcium with acute coronary syndrome and culprit lesions in patients with acute chest pain: The coronary calcium paradox. Atherosclerosis 274:251-257
Hedgire, Sandeep; Baliyan, Vinit; Zucker, Evan J et al. (2018) Perivascular Epicardial Fat Stranding at Coronary CT Angiography: A Marker of Acute Plaque Rupture and Spontaneous Coronary Artery Dissection. Radiology 287:808-815
Bittner, Daniel O; Mayrhofer, Thomas; Puchner, Stefan B et al. (2018) Coronary Computed Tomography Angiography-Specific Definitions of High-Risk Plaque Features Improve Detection of Acute Coronary Syndrome. Circ Cardiovasc Imaging 11:e007657
Genders, Tessa S S; Coles, Adrian; Hoffmann, Udo et al. (2018) The External Validity of Prediction Models for the Diagnosis of Obstructive Coronary Artery Disease in Patients With Stable Chest Pain: Insights From the PROMISE Trial. JACC Cardiovasc Imaging 11:437-446
Lu, Michael T; Meyersohn, Nandini M; Mayrhofer, Thomas et al. (2018) Central Core Laboratory versus Site Interpretation of Coronary CT Angiography: Agreement and Association with Cardiovascular Events in the PROMISE Trial. Radiology 287:87-95
Alvi, Raza M; Neilan, Anne M; Tariq, Noor et al. (2018) Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure. J Am Coll Cardiol 72:518-530
deFilippi, Christopher; Christenson, Robert; Joyce, Jessica et al. (2018) Brief Report: Statin Effects on Myocardial Fibrosis Markers in People Living With HIV. J Acquir Immune Defic Syndr 78:105-110

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