The proposed midcareer investigator Award in Patient-Oriented Research (K24) will support the career development of Helen Blair Simpson, MD PhD, a clinical researcher who is dedicated to improving the lives of people with obsessive-compulsive disorder (OCD). The Career Development Plan will enhance the candidate's ability 1) to conduct patient-oriented research by receiving training in three specific areas: functional magnetic resonance imaging, advanced statistical methods, and novel clinical trial designs;and 2) to mentor patient-oriented researchers by receiving training in scientific leadership and cultural competence. The Mentoring Plan describes training for research fellows, K-awardees, and junior faculty in patient-oriented research. Under supervision by the candidate, mentees will obtain hand-on experience in methods for conducting patient-oriented research and will develop their own independent research directions. The Research Plan includes funded projects that focus on clinical trials but that also include neuroimaging and translational studies that Dr. Simpson conducts in collaboration with imaging experts and basic scientists, making for a rich training environment. It also includes a New Research Project with two aims: 1) to identify neurocognitive, neurophysiological, and neuroimaging biomarkers for OCD;and 2) to explore whether the pattern of performance across these measures generates a new way to classify OCD. Capitalizing on existing resources so as to be accomplished within the limits of the K24 research budget, this project will 1) enhance Dr. Simpson's research program and advance her capacity to conduct patient-oriented research; and 2) provide excellent opportunities for mentoring clinician-investigators.

Public Health Relevance

This is a grant application for a Midcareer Investigator Award in Patient-Oriented Research (K24) to enable Dr. Helen Blair Simpson to advance her capacity to conduct patient-oriented research and to enhance her ability to mentor clinician-investigators who seek to conduct patient-oriented research. The application is based on the candidate's interdisciplinary program focused on obsessive-compulsive disorder (OCD). It proposes a focused training program for the candidate, a plan for mentoring clinician-investigators in patient-oriented research, and a pilot project to identify biomarkers/behavioral indicators for OCD, an objective of the NIMH strategic plan.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
1K24MH091555-01
Application #
7981769
Study Section
Special Emphasis Panel (ZMH1-ERB-F (08))
Program Officer
Meinecke, Douglas L
Project Start
2010-09-01
Project End
2015-04-30
Budget Start
2010-09-01
Budget End
2011-04-30
Support Year
1
Fiscal Year
2010
Total Cost
$149,543
Indirect Cost
Name
Columbia University (N.Y.)
Department
Psychiatry
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Wheaton, Michael G; Gershkovich, Marina; Gallagher, Thea et al. (2018) Behavioral avoidance predicts treatment outcome with exposure and response prevention for obsessive-compulsive disorder. Depress Anxiety 35:256-263
Patel, Sapana R; Wheaton, Michael G; Andersson, Erik et al. (2018) Acceptability, Feasibility, and Effectiveness of Internet-Based Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder in New York. Behav Ther 49:631-641
Kalanthroff, Eyal; Teichert, Tobias; Wheaton, Michael G et al. (2017) The Role of Response Inhibition in Medicated and Unmedicated Obsessive-Compulsive Disorder Patients: Evidence from the Stop-Signal Task. Depress Anxiety 34:301-306
Posner, Jonathan; Song, Inkyung; Lee, Seonjoo et al. (2017) Increased functional connectivity between the default mode and salience networks in unmedicated adults with obsessive-compulsive disorder. Hum Brain Mapp 38:678-687
Patel, Sapana R; Galfavy, Hanga; Kimeldorf, Marcia B et al. (2017) Patient Preferences and Acceptability of Evidence-Based and Novel Treatments for Obsessive-Compulsive Disorder. Psychiatr Serv 68:250-257
Rodriguez, Carolyn I; Lapidus, Kyle A B; Zwerling, Jordana et al. (2017) Challenges in Testing Intranasal Ketamine in Obsessive-Compulsive Disorder. J Clin Psychiatry 78:466-467
Steinglass, Joanna E; Lempert, Karolina M; Choo, Tse-Hwei et al. (2017) Temporal discounting across three psychiatric disorders: Anorexia nervosa, obsessive compulsive disorder, and social anxiety disorder. Depress Anxiety 34:463-470
Kalanthroff, Eyal; Linkovski, Omer; Weinbach, Noam et al. (2017) What underlies the effect of sleep disruption? The role of alertness in obsessive-compulsive disorder (OCD). J Behav Ther Exp Psychiatry 57:212-213
Schneier, Franklin R; Kimeldorf, Marcia B; Choo, Tse Hwei et al. (2016) Attention bias in adults with anorexia nervosa, obsessive-compulsive disorder, and social anxiety disorder. J Psychiatr Res 79:61-69
Rodriguez, Carolyn I; Levinson, Amanda; Zwerling, Jordana et al. (2016) Open-Label trial on the effects of memantine in adults with obsessive-compulsive disorder after a single ketamine infusion. J Clin Psychiatry 77:688-9

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