Patient-oriented outcomes investigation is essential for the advancement of clinical research and care of chronic neurological conditions such as epilepsy, which have complex interactions of cognitive, emotional, social, vocational and iatragenic factors. We intend to utilize a prospective randomized trial (R01 NS40808) that compares the effects of a selective serotonin re-uptake inhibitor and cognitive behavior therapy on mood, medication compliance, seizures, and health outcomes in persons with co-morbid epilepsy and depression to support training of junior investigators in clinical research methods. Upcoming funded research studies will apply innovative strategies to advance patient-oriented neuroscience, such as 18FDG-PET co-registration with structural MRI for regional parametric statistical mapping of metabolic variability and Depression Inventory Scores to study the association of dysfunction in specific brain regions with severity of symptoms of depression. We will implement a weekly Seminar in Patient-Oriented Research to provide mentoring on the application of biostatistics, study design and interpretation, and logistical strategies in clinical research. This seminar will also be used to facilitate the development, implementation, and analysis of research projects performed by trainees. Participants will include junior faculty with clinical K-series Awards, epilepsy fellows, our departmental NIH-supported training grant awardees (four/year), and academically oriented residents. This program should allow improvement in the quality and quantity of future patient-oriented research in neuroscience through longitudinal intensive training and mentoring of junior investigators. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
7K24NS047551-02
Application #
6888926
Study Section
NST-2 Subcommittee (NST)
Program Officer
Fureman, Brandy E
Project Start
2004-05-01
Project End
2009-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
2
Fiscal Year
2005
Total Cost
$143,035
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
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Hecimovic, H; Santos, J M; Carter, J et al. (2012) Depression but not seizure factors or quality of life predicts suicidality in epilepsy. Epilepsy Behav 24:426-9
Kanner, Andres M; Barry, John J; Gilliam, Frank et al. (2012) Depressive and anxiety disorders in epilepsy: do they differ in their potential to worsen common antiepileptic drug-related adverse events? Epilepsia 53:1104-8
Kanner, Andres M; Schachter, Steven C; Barry, John J et al. (2012) Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence. Epilepsy Behav 24:156-68
Stern, John M; Labiner, David M; Gilliam, Frank G et al. (2011) More effective assessment of adverse effects and comorbidities in epilepsy: results of a Phase II communication study. Epilepsy Behav 22:552-6
Chaytor, Naomi; Ciechanowski, Paul; Miller, John W et al. (2011) Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy. Epilepsy Behav 20:545-9
Perucca, Piero; Hesdorffer, Dale C; Gilliam, Frank G (2011) Response to first antiepileptic drug trial predicts health outcome in epilepsy. Epilepsia 52:2209-15

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