Dr. Cynthia K. Sites is an Associate Professor of Obstetrics and Gynecology and Director of the Fellowship Program in Reproductive Endocrinology and Infertility at the University of Vermont College of Medicine. Dr. Sites' major research goal is to understand and develop new therapeutic strategies to alleviate increased cardiovascular disease risk following menopause. This K24 Midcareer Award in Patient-Oriented Research will ensure that Dr. Sites devotes at least 40% of her effort to patient-oriented research and mentoring of clinical investigators. Although Dr. Sites has conducted several patient-oriented research projects toward this goal, this proposal describes Dr. Sites' study, """"""""Soy Phytoestrogens and Metabolic Cardiovascular Risk."""""""" Since the publication of the Women's Health Initiative findings, postmenopausal women are discontinuing hormone replacement therapy and considering alternative strategies such as soy phytoestrogens. Our overall hypothesis is that dietary supplementation with soy phytoestrogens improves glucose metabolism by increasing glucose disposal and reducing insulin secretion, which reduce the risk of cardiovascular disease. Fellows to be mentored by Dr. Sites through this K24 award will be trained to develop hypotheses and carry out projects consistent with these goals. The Candidate has demonstrated continued commitment to mentoring and training fellows, residents, and medical students in Patient-Oriented Research, and has the full support of her department and the General Clinical Research Center for this project.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Midcareer Investigator Award in Patient-Oriented Research (K24)
Project #
5K24RR019705-04
Application #
7057270
Study Section
Reproductive Endocrinology Study Section (REN)
Program Officer
Wilde, David B
Project Start
2004-05-01
Project End
2009-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
4
Fiscal Year
2006
Total Cost
$132,884
Indirect Cost
Name
University of Alabama Birmingham
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Christie, Daniel R; Grant, Jan; Darnell, Betty E et al. (2010) Metabolic effects of soy supplementation in postmenopausal Caucasian and African American women: a randomized, placebo-controlled trial. Am J Obstet Gynecol 203:153.e1-9
Wellons, Melissa F; Lewis, Cora E; Schwartz, Stephen M et al. (2008) Racial differences in self-reported infertility and risk factors for infertility in a cohort of black and white women: the CARDIA Women's Study. Fertil Steril 90:1640-8
Sites, Cynthia K (2008) Bioidentical hormones for menopausal therapy. Womens Health (Lond Engl) 4:163-71
Sites, Cynthia K; Cooper, Brian C; Toth, Michael J et al. (2007) Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal women. Fertil Steril 88:1609-17
Cooper, Brian C; Burger, Natalie Z; Toth, Michael J et al. (2007) Insulin resistance with hormone replacement therapy: associations with markers of inflammation and adiposity. Am J Obstet Gynecol 196:123.e1-7
Goodrow, Gwen J; L'Hommedieu, Georgia D; Gannon, Barbara et al. (2006) Predictors of worsening insulin sensitivity in postmenopausal women. Am J Obstet Gynecol 194:355-61