Helical tomotherapy (1.) is a new IMRT technology for radiation treatment of cancer, invented here at the University of Wisconsin - Madison, and is in the initial stages of operation at the University of Wisconsin Comprehensive Cancer Center. It is the marriage of a linac with a CT scanner. The delivered dose uniformity is potentially compromised in helical tomotherapy by unique delivery """"""""artifacts"""""""" that arise from inherent geometrical constraints in the device as well as target motion common to all IMRT technologies. The proposed work involves the exploration of the thread artifact arising from the small cone-angle of the Fan-beam, the discrete delivery artifact arising from the phasing of the 51 delivery angles, and a motion artifact, similar to other IMRT technologies, but with different parameters in current tomotherapy device. The candidate, Dr. Michael Kissick, is an established scientist in plasma physics and nuclear fusion, but has recently switched fields into medical physics, bringing a great deal of physical science research and analytical skills to the medical field. The goal of the project is to develop viable solutions to these artifacts, while small for most situations, can be larger for some challenging cases such as large field plans that would require a high pitch delivery. Such solutions would extend the applicability of tomotherapy in its clinical use in cancer treatment. ? ? 1. """"""""Helical Tomotherapy,"""""""" T.R. Mackie, et al., Intensity Modulated Radiation Therapy - The State of the Art, ed. J.R. Palta and T.R. Mackie, Proceedings of the American Association of Physicists in Medicine (AAPM) 2003 Summer School Proceedings, Colorado Springs, CO, June 22-26, 2003, page 247, Medical Physics Monograph No. 29, Medical Physics Publishing, Madison, Wl. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Mentored Quantitative Research Career Development Award (K25)
Project #
5K25CA119344-02
Application #
7415149
Study Section
Subcommittee G - Education (NCI)
Program Officer
Jakowlew, Sonia B
Project Start
2007-05-01
Project End
2010-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
2
Fiscal Year
2008
Total Cost
$134,807
Indirect Cost
Name
University of Wisconsin Madison
Department
Physics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Kissick, Michael W; Mackie, Thomas R; Flynn, Ryan T et al. (2012) Investigation of probabilistic optimization for tomotherapy. J Appl Clin Med Phys 13:3865
McCall, Keisha C; Barbee, David L; Kissick, Michael W et al. (2010) PET imaging for the quantification of biologically heterogeneous tumours: measuring the effect of relative position on image-based quantification of dose-painting targets. Phys Med Biol 55:2789-806
Kissick, Michael W; Mo, Xiaohu; McCall, Keisha C et al. (2010) A phantom model demonstration of tomotherapy dose painting delivery, including managed respiratory motion without motion management. Phys Med Biol 55:2983-95
Kissick, Michael W; Mackie, T Rockwell (2009) Task Group 76 Report on 'The management of respiratory motion in radiation oncology' [Med. Phys. 33, 3874-3900 (2006)]. Med Phys 36:5721-2
Kissick, Michael W; Flynn, Ryan T; Westerly, David C et al. (2008) On the impact of longitudinal breathing motion randomness for tomotherapy delivery. Phys Med Biol 53:4855-73
Kissick, Michael W; Flynn, Ryan T; Westerly, David C et al. (2007) On the making of sharp longitudinal dose profiles with helical tomotherapy. Phys Med Biol 52:6497-510