The long-term objective of this application is to establish the candidate as a leading member of multi-disciplinary research teams and as an independent researcher in statistical methodology for neuroimaging studies. The training plan complements the candidate?s strong statistical background by providing foundations in neuroscience, biomedical imaging, and mental health. The research plan focuses on new statistical methods for neuroimaging studies of mental health, in particular, schizophrenia, anxiety disorder, and addiction.
One aim i s to develop state-of-the-art statistical methodology to identify brain regions exhibiting similar functional magnetic resonance imaging (fMRI) profiles. Displays of colored brain images will distinguish clusters, and dynamic images will depict cluster changes across times, study conditions, or distance metrics. Several clustering methods will be compared and approximate approaches will be developed to increase computational efficiency. The clustering methodology will allow evaluation of the use of multiple brain regions by subjects when performing tasks, experiencing emotional states, or exhibiting certain behaviors.
Other specific aims i nclude developing statistical models for positron emission tomography (PET) and fMRI data incorporating intra-subject correlation. One method will use linear models with correlated errors and random effects. A second method will use Bayesian hierarchical models directly accounting for spatial correlation between and temporal correlation within brain voxels through various covariance models. Another approach will model temporal correlation directly and spatial correlation indirectly through prior distributions of voxel-specific parameters, e.g., pnors inducing similarity for neighboring voxels. Also, spatial networks will be extended to include voxels that are ?close? according to anatomical or physiological connections. Computer software for these research developments will be made accessible to neuroimaging scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Mentored Quantitative Research Career Development Award (K25)
Project #
5K25MH065473-03
Application #
6796422
Study Section
Special Emphasis Panel (ZRG1-BDCN-6 (01))
Program Officer
Desmond, Nancy L
Project Start
2002-09-10
Project End
2007-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
3
Fiscal Year
2004
Total Cost
$94,679
Indirect Cost
Name
Emory University
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Guo, Ying; Bowman, F DuBois (2008) Modeling dose-dependent neural processing responses using mixed effects spline models: with application to a PET study of ethanol. Neuroimage 40:698-711
Guo, Ying; DuBois Bowman, F; Kilts, Clinton (2008) Predicting the brain response to treatment using a Bayesian hierarchical model with application to a study of schizophrenia. Hum Brain Mapp 29:1092-109
DuBois Bowman, F; Caffo, Brian; Bassett, Susan Spear et al. (2008) A Bayesian hierarchical framework for spatial modeling of fMRI data. Neuroimage 39:146-56
Bowman, F Dubois; Guo, Ying; Derado, Gordana (2007) Statistical approaches to functional neuroimaging data. Neuroimaging Clin N Am 17:441-58, viii
Kilts, Clinton D; Kelsey, Jeffrey E; Knight, Bettina et al. (2006) The neural correlates of social anxiety disorder and response to pharmacotherapy. Neuropsychopharmacology 31:2243-53
Patel, Rajan S; Van De Ville, Dimitri; Bowman, F DuBois (2006) Determining significant connectivity by 4D spatiotemporal wavelet packet resampling of functional neuroimaging data. Neuroimage 31:1142-55
Bowman, F Dubois (2005) Spatio-temporal modeling of localized brain activity. Biostatistics 6:558-75
Bowman, F DuBois; Patel, Rajan; Lu, Chengxing (2004) Methods for detecting functional classifications in neuroimaging data. Hum Brain Mapp 23:109-19
Bowman, F DuBois; Waller, Lance A (2004) Modelling of cardiac imaging data with spatial correlation. Stat Med 23:965-85
Bowman, F DuBois; Stewart, Paul W; Sen, Pranab K et al. (2004) Making inferences about projected completors in longitudinal studies. J Biopharm Stat 14:947-67

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