Funding is requested to advance the research career of the Candidate, Dr. Paul K. Maciejewski. The overall aim of the project is to establish the Candidate, whose prior formal training has been in mechanical engineering and statistics, as an independent investigator in the areas of neurophysiology and brain functional magnetic resonance imaging (fMRI). The research career development plan consists of education/training and research components. Education in neurophysiology will be obtained primarily through courses offered in the Graduate Program in Neurobiology in the Yale University School of Medicine. Training in magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), and metabolic modeling will be obtained primarily through training provided by experienced researchers at the Yale University Magnetic Resonance Center for Research in Metabolism & Physiology. Education and training in the ethical use of animals in research will be obtained primarily through the Yale Animal Resources Center. The research plan has three Specific Aims. These are: 1) Developing a 13C MRS method for measuring dynamic changes in cerebral metabolic rate of oxygen consumption, 2) obtaining dynamic, multi-modal measurements of functional activation in a rat model, and 3) developing a neurovascular model of blood oxygenation level dependent (BOLD) signal and functional activation.
The Aims of the research plan will be achieved through applications and extensions of MRS, metabolic modeling, fMRI, electrophysiological measurements, and dynamic modeling. The outcomes of this basic research are expected to be relevant to diagnostic evaluation in neurology and psychiatry.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Mentored Quantitative Research Career Development Award (K25)
Project #
5K25NS044316-02
Application #
6660368
Study Section
NST-2 Subcommittee (NST)
Program Officer
Babcock, Debra J
Project Start
2002-09-18
Project End
2007-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
2
Fiscal Year
2003
Total Cost
$141,656
Indirect Cost
Name
Yale University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Prigerson, Holly G; Horowitz, Mardi J; Jacobs, Selby C et al. (2009) Prolonged grief disorder: Psychometric validation of criteria proposed for DSM-V and ICD-11. PLoS Med 6:e1000121
Cosgrove, Kelly P; Batis, Jeffery; Bois, Frederic et al. (2009) beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Arch Gen Psychiatry 66:666-76
Hains, Avis Brennan; Vu, Mai Anh T; Maciejewski, Paul K et al. (2009) Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress. Proc Natl Acad Sci U S A 106:17957-62
Calhoun, Vince D; Maciejewski, Paul K; Pearlson, Godfrey D et al. (2008) Temporal lobe and ""default"" hemodynamic brain modes discriminate between schizophrenia and bipolar disorder. Hum Brain Mapp 29:1265-75
Maciejewski, Paul K; Rothman, Douglas L (2008) Proposed cycles for functional glutamate trafficking in synaptic neurotransmission. Neurochem Int 52:809-25
Cosgrove, Kelly P; Mitsis, Effie M; Bois, Frederic et al. (2007) 123I-5-IA-85380 SPECT imaging of nicotinic acetylcholine receptor availability in nonsmokers: effects of sex and menstrual phase. J Nucl Med 48:1633-40
Maciejewski, Paul K; Zhang, Baohui; Block, Susan D et al. (2007) An empirical examination of the stage theory of grief. JAMA 297:716-23
Kida, Ikuhiro; Maciejewski, Paul K; Hyder, Fahmeed (2004) Dynamic imaging of perfusion and oxygenation by functional magnetic resonance imaging. J Cereb Blood Flow Metab 24:1369-81
Trubel, Hubert; Herman, Peter; Kampmann, Christoph et al. (2004) A novel approach for selective brain cooling: implications for hypercapnia and seizure activity. Intensive Care Med 30:1829-33
Trubel, Hubert K F; Maciejewski, Paul K; Farber, Jacqueline H et al. (2003) Brain temperature measured by 1H-NMR in conjunction with a lanthanide complex. J Appl Physiol 94:1641-9