Pre-surgical evaluation benefits from information about the location of functional brain systems and dysfunctional tissue. Recently, methods based on analysis of spontaneous activity measured by functional MRI have shown promise for identifying brain systems in subjects resting and while asleep. Here we will develop and evaluate a novel method using rest-state intrinsic activity to map multiple systems within the brain including language, memory, and motor systems. Specifically, this project aims to address three critical challenges in pre-surgical mapping. First, this project will seek to develop a new language and memory lateralization technique as a candidate to replace the traditional invasive Wada test. Second, we hypothesize that essential areas of cortex can be mapped using intrinsic functional connectivity linked to specific brain systems. Finally, by assessing the disruption of functional connectivity, we will seek to localize brain lesions and epileptogenic cortex. This project proposes a new approach for pre-surgical mapping for patients with brain lesions and has the potential to significantly improve surgical planning.
This project aims to replace the traditional pre-surgical mapping by providing a means to determine functional laterality, eloquent cortex and epileptic foci simultaneously and with minimal task requirements.
| Langs, Georg; Wang, Danhong; Golland, Polina et al. (2016) Identifying Shared Brain Networks in Individuals by Decoupling Functional and Anatomical Variability. Cereb Cortex 26:4004-14 |
| Fox, Michael D; Qian, Tianyi; Madsen, Joseph R et al. (2016) Combining task-evoked and spontaneous activity to improve pre-operative brain mapping with fMRI. Neuroimage 124:714-723 |
| Douw, Linda; DeSalvo, Matthew N; Tanaka, Naoaki et al. (2015) Dissociated multimodal hubs and seizures in temporal lobe epilepsy. Ann Clin Transl Neurol 2:338-52 |
| Zhang, Miao; Lin, Qixiang; Lu, Jie et al. (2015) Pontine infarction: diffusion-tensor imaging of motor pathways-a longitudinal study. Radiology 274:841-50 |
| Mueller, Sophia; Wang, Danhong; Pan, Ruiqi et al. (2015) Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia. JAMA Psychiatry 72:552-60 |
| Boes, Aaron D; Prasad, Sashank; Liu, Hesheng et al. (2015) Network localization of neurological symptoms from focal brain lesions. Brain 138:3061-75 |
| Mueller, Sophia; Wang, Danhong; Fox, Michael D et al. (2015) Reliability correction for functional connectivity: Theory and implementation. Hum Brain Mapp 36:4664-80 |
| Wang, Danhong; Buckner, Randy L; Fox, Michael D et al. (2015) Parcellating cortical functional networks in individuals. Nat Neurosci 18:1853-60 |
| Fox, Michael D; Buckner, Randy L; Liu, Hesheng et al. (2014) Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases. Proc Natl Acad Sci U S A 111:E4367-75 |
| Zeng, Ling-Li; Wang, Danhong; Fox, Michael D et al. (2014) Neurobiological basis of head motion in brain imaging. Proc Natl Acad Sci U S A 111:6058-62 |
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