Statetheapplicationsbroad,long-termobjectivesand specificaims,makingreferenceto thehealthrelatednessof the project. Describeconciselythe researchdesignand methodsfor achievingthesegoals.Avoidsummariesof pastaccomplishmentsandthe useof the firstperson.Thisdescriptionis meanttoserve as a succinctand accuratedescriptionof the proposedworkwhenseparatedfromtheapplication. Ifthe applicationis funded, thisdescription,as is,will becomepublicinformationT. herefore,donotincludeproprietary/confidentiailnformationD.ONOTEXCEEDTHESPACEPROVIDED.The initial funding of the University of Pittsburgh's K-30 application resulted in the development of our Clinical ResearchTraining Program (CRTP), which has become an important foundation for clinical research at the University of Pittsburgh.We have trained 68 participants and 43 other individuals have participated in courses developed through the CRTP. Theseexperiences and the feedback from these trainees form the basis for our competitive renewal, which seeks to enhance theCRTP program through the following specific Aims:
Aim 1) Expand and enhance access to the CRTP training program. Our current program is directed toward juniorfaculty and fellows. However, trainees may make decisions regarding career paths earlier, and may be lost to the clinicalresearch community. Therefore, we will develop clinical research training programs for residents (a clinical research tractwithin the context of ACGME approved residencies) and develop a clinical research program for medical students, theClinical Scientist Training Program (CSTP). CSTP will enroll 10 students in a five year program and additional 4 residents willbe accepted into CRTP per year. Additionally, in order to assure access to our programs for trainees of all levels and withdifferent clinical responsibilities, and to enable trainees to continue to learn while offsite, we will develop a series of web-based courses that offer components of the curriculum that can be taken at various times and at an individualized pace.
Aim 2.) Expand and enhance the CRTP curriculum to meet rapidly changing clinical research training needs. Oneof the successful components of our program has been our ability to develop and modify courses in response to traineeneeds, and these mechanisms will be enhanced and formalized. Based on current feedback from trainees, strong supportfrom our curriculum advisory committee and consistent with the recommendations of the NIH Roadmap, we will develop atract in translational research. This track will provide skills and knowledge necessary to promote multi- and inter-disciplinarycollaborations that are essential to translational research and will enhance the movement of scientific discovery to clinical practice.
Aim 3.) Develop a formal menmring program. Mentors play a pivotal role in developing new investigators, and we planto devote extensive efforts to strengthening our mentoring activities by developing training and educational activities forboth mentors and mentees, monitoring of mentoring activities, and developing mechanisms to intervene early when problems are identifiedPERFORMANCESITE(S) (organization,city, state)University of Pittsburgh, Pittsburgh, PAKEY PERSONNEL. See instructionosn page11. Use continuationpages as neededto providethe requiredinformation inthe format shown below. Name Organization Role in ProjectWishwa N. Kapoor, MD, MPH University of Pittsburgh DirectorRobert Branch University of Pittsburgh Co-DirectorMark Roberts University of Pittsburgh Co-DirectorJennifer Grandis University of Pittsburgh Translational Track DirectorJoan M. Lakoski University of Pittsburgh Mentoring Program DirectorJames B. McGee University of Pittsburgh Web-based Curriculum DirectorDavid Barnard University of Pittsburgh Curriculum Committee MemberJoyce Chang University of Pittsburgh Curriculum Committee MemberDoris Rubio University of Pittsburgh Data Management DirectorPHS 398 (Rev. 5/95) Page BBNumberoaaesconsecutivelyat the bottomthrouahoutthe aoolication. Donot usesuffixessuchas 3a. 3b. Principal Investigator/Program Director (Last, First, Middle):The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT
