State the application's broad, long-term objectives and specific aims, making reference to the health relatedness of the project. Describeconcisely the research design and methods for achieving these goals. Avoid summaries of past accomplishmentsand the use of the first person. This abstractis meant to serve as a succinct and accurate descdption of the proposed work when separated from the application, If the application is funded, thisdescription, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT EXCEED THE SPACEPROVIDED.The complexities of clinical research and translational research over the past 10 years have placed additionaldemands for mastery of a new set of research skills for clinical investigators. The K30-funded HumanInvestigations Program (HIP) was established four years ago to meet the needs of OHSU faculty and fellows, andcommunity affiliates. The program consists of a didactic component coupled with a mentored researchexperience; we propose to add an experiential component in the next grant period. The didactic courses weredeveloped around the accepted core competencies for research: clinical research study design, biostatistics,medical informatics, ethics of human research, and scientific writing and communication. To these, we addtranslational research and health services research. Elective courses in the HIP program include data management,randomized clinical trials, evidence-based medicine and effective clinical teaching. All residency and fellowshipresearch courses have been consolidated into this program. The HIP courses are created and taught by senior,experienced educators using principles of adult education. In the mentored research experience, each student isworks with a mentor to write either an NIH-style grant or to design, implement, and write a manuscript on aclinical research project. In the proposed experiential learning, HIP trainees will have opportunities to participatein grant review, IRB meetings, or molecular biology lab work, as examples. All trainees evaluate the courses inthe curriculum and the entire program is evaluated in a focus group setting at the end of each year. Completion ofthe HIP program results in awarding a Certificate of Training in Human Investigation; a Master of ClinicalResearch has been approved at OHSU and is pending approval by the Oregon University System.At present, HIP has enrolled 86 into the degree cohort and 48 into the non-degree cohort. Of the initial cohort of31 who matriculated in the degree track, 78% have graduated or remain active in the program; of the secondcohort of 29, 90% remain active; of the third cohort, of 26, 96% remain enrolled. In the first cohort to complete theprogram, 80 % have submitted at least one research grant, and 73% currently have research support.PERFORMANCE SITE(S) (organization, city, state)Oregon Health & Science University, Portland, OregonKEY PERSONNEL. See instructions. Use continuagon pages as needed to provide the required information in the format shown below.Start with Principal Investigator. List all other key personnel in alphabetical order, last name first. Name Organization Role on ProjectMorris, Cynthia D., PhD, MPH OHSU Program directorAssael, Leon, DMD OHSU Course directorBagby, Grover C. Jr., MD OHSU Course directorBecker, Thomas, MD, PhD OHSU Course directorBeemsterboer, Phyllis, MS, EdD OHSU Program evaluatorBerlin, Michelle, MD, MPH OHSU Course directorBowen, Judith, MD OHSU Course directorBrandon, David D., PhD OHSU Course directorChan, Benjamin, MS OHSU Statistical consultantChiodo, Gary, DMD, FACD OHSU Course directorHelfand, Mark, MD, MPH OHSU Course directorDisclosure Permission Statement. Applicable to SBIR/STTR Only. See instructions. [] Yes [] NoPHS 398 (Rev. 05/01 ) Page 2 Numberpagesconsecutivelyatthe bottomthroughout Form Page 2 theapplication,Do notuse suffixesuchas 2a, 2b.Principal InvestigatodProgram Director (Last, First, Middle): Morris, Cynthia D.Name OrganizationHersh, William, MD OHSULapidus, Jodi, PhD OHSUMcCracken, Karen, BA, BSN OHSUMori, Motomi, PhD OHSUOrwoll, Eric S, MD OHSUSamuels, Mary, MD OHSUSchuff, Robert, MS OHSUPHS 398/2590 (Rev. 05/01) Page 3Role on ProjectCourse directorCourse directorProgram CoordinatorCourse directorCourse directorCourse directorCourse directorContinuation Format Page PrincipInavelstigator/Program Director (Last, First, Middle): Morris, Cynthia D.The name of the principal investigator/program director must be provided at the top of each printed page and each continuation page. RESEARCH GRANT
| Chang, Eugene Y; Morris, Cynthia D; Seltman, Ann K et al. (2007) The effect of antireflux surgery on esophageal carcinogenesis in patients with barrett esophagus: a systematic review. Ann Surg 246:11-21 |
