Abstract

Public Health Relevance

My project seeks to understand the role of pyruvate kinase as regulator of cancer metabolism. Insights into glutamine influx of proliferating cells will reveal new drug targets and generate new regimes for diagnosis and treatment of cancer patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Career Transition Award (K99)
Project #
5K99CA154887-02
Application #
8305666
Study Section
Subcommittee G - Education (NCI)
Program Officer
Schmidt, Michael K
Project Start
2011-07-21
Project End
2012-07-29
Budget Start
2012-07-01
Budget End
2012-07-29
Support Year
2
Fiscal Year
2012
Total Cost
$88,646
Indirect Cost
$6,566

  Institution

Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037

  Publications

Zecena, Helma; Tveit, Daniel; Wang, Zi et al. (2018) Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma. BMC Syst Biol 12:33
Wilson, Stephen; Filipp, Fabian Volker (2018) A network of epigenomic and transcriptional cooperation encompassing an epigenomic master regulator in cancer. NPJ Syst Biol Appl 4:24
Singh, Simar J; Turner, William; Glaser, Drew E et al. (2017) Metabolic shift in density-dependent stem cell differentiation. Cell Commun Signal 15:44
Lanning, Nathan J; Castle, Joshua P; Singh, Simar J et al. (2017) Metabolic profiling of triple-negative breast cancer cells reveals metabolic vulnerabilities. Cancer Metab 5:6
Filipp, Fabian V (2017) Precision medicine driven by cancer systems biology. Cancer Metastasis Rev 36:91-108
Wilson, Stephen; Fan, Lingling; Sahgal, Natasha et al. (2017) The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cells. Oncotarget 8:30328-30343
Filipp, Fabian V (2017) Crosstalk between epigenetics and metabolism-Yin and Yang of histone demethylases and methyltransferases in cancer. Brief Funct Genomics 16:320-325
Wilson, Stephen; Qi, Jianfei; Filipp, Fabian V (2016) Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines. Sci Rep 6:32611
Tiffen, Jessamy; Wilson, Stephen; Gallagher, Stuart J et al. (2016) Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma. Neoplasia 18:121-32
Edwards, Lauren; Gupta, Rohit; Filipp, Fabian Volker (2016) Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression. Mol Cancer Res 14:196-206

Showing the most recent 10 out of 20 publications