I am a developmental cognitive neuroscientist. My overall career objectives are to develop effective methods to prevent, diagnose and alleviate language and related learning disabilities in children. I aspire to perform translational neuroscience research either as a faculty member in a psychology or neuroscience department or as a clinical research faculty in a pediatric or neurology department. To become an independent scientist capable of designing, administering, and assessing interventions for improving language outcomes in children, I require additional training in randomized clinical trial methodology, including biostatistical analyses. I will obtain this training by taking selected coursework at Stanford, participating in professional activities and workshops, and performing a RCT that I have independently developed. I have organized a team of international scientific experts who are committed to helping me achieve these skills and career goals. Children born preterm are at-risk for developmental language delays. Language problems in preterm children are thought to be related to neurobiological factors, including injuries to white matter structures of the brain and environmental factors, including decreased exposure to maternal speech in the hospital nursery. There is strong evidence to suggest that maternal speech input may be important for promoting healthy brain and language development. Recently, several studies have demonstrated that recordings of a mother's voice played to preterm infants in hospital nurseries can improve short-term health outcomes. Here, we propose a randomized clinical trial to examine whether exposure to recordings of a mothers voice can improve both white matter and language development in preterm infants. We will assess both the short and long-term impacts of this language intervention on neural, clinical and language outcomes. Findings from the proposed study will have important implications for guiding clinical practices and treatments for minimizing language impairments in preterms and other pediatric populations at-risk for language disorders. The studies proposed here have the potential to advance understanding for how language experience directly influences changes in brain structures as well as for the neural bases of recovery following early white matter injury and for plasticity. In summary, the proposed studies will make important contributions to theoretical research on brain and language development and to clinical practice.

Public Health Relevance

Children born preterm are at-risk for developmental language delays. Language problems in preterm children are thought to be related to neurobiological factors, including injuries to white matter structures of the brain and environmental factors, including decreased exposure to maternal speech in the hospital nursery. To help minimize these problems, the present research aims to demonstrate that a language intervention, which involves playing recordings of a mother's voice to the infant while s/he is in the hospital nursery will be effective for promoting healthy brain and language development in preterm babies.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Career Transition Award (K99)
Project #
5K99HD084749-02
Application #
9264003
Study Section
Biobehavioral and Behavioral Sciences Subcommittee (CHHD-H)
Program Officer
Alvarez, Ruben P
Project Start
2016-06-01
Project End
2018-05-31
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
2
Fiscal Year
2017
Total Cost
$127,683
Indirect Cost
$9,458
Name
Stanford University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304
Dodson, Cory K; Travis, Katherine E; Borchers, Lauren R et al. (2018) White matter properties associated with pre-reading skills in 6-year-old children born preterm and at term. Dev Med Child Neurol 60:695-702
Dodson, Cory K; Travis, Katherine E; Ben-Shachar, Michal et al. (2017) White matter microstructure of 6-year old children born preterm and full term. Neuroimage Clin 16:268-275