Applying for our second CTSA, Tufts Clinical and Translational Science Institute (CTSl) remains avidly committed to involving the full spectrum of clinical ahd translational research (CTR) to meet th(c) promise of biomedical science, not only bench to bedside (T1) translation, crucial to having health impact, translation into effective clinical practice (T2), care delivery and public health (T3), and health policy ('T4). In 2008 we started Tufts CTSI building on prior CTR resources, services, and educational programs, we purposely selected partners that would leverage and complement each other's special assets. Our 38 strategically- chosen partners include 12 Tufts University schools/research centers, ten Tufts hospitals, three academic institutions (Brandeis University, Northeastern University, RAND Corporation), eight community-based organizations, and five industry partners, an outstanding and synergistic resources, opportunities, and education across the T1-T4 spectrum. Described in our application's four sections are four aims that build on this platform:
AIM 1 : Strengthen Tufls CTSI overall by; 1) organizing and leading its partners in their commitment to this shared home for CTR; 2) expanding efficient access for ail partners to a full spectrum of high-quality resources in a way that promotes collaborative CTR across disciplines and institutions;3) advancing the field of CTR through local and national leadership and development of novel methods;4) providing innovative and targeted education and training across the T1-4 spectrum. (Section I) AIM 2: Operationalize and implement the CTR home and its infra- stnjcture, sen/ices and programs, including Its central office personnel, administrative and financial management systems, committees, and other necessary structures. (Section II) AIM 3: Sustain and grow innovative resources, services, and policies that support and promote collaborative, cross-disciplinary, full-spectrum translational research. (Section III) AIM 4:Develop and broaden the CTR workforce through education and training across the T1-T4 spectrum, with a specific focus on addressing translational gaps between bench to bedside and from bedside to widespread impact on health. (Section IV)

Public Health Relevance

(See Instructions): Tufts Clinical and Translational Science Institute uses the entire spectrum of clinical and translational research (CTR) to help meet the promise and the public's needs of biomedical science.This includes bench to bedside (Tl) translation and crucially for having health impact, translation into effective clinical practice (T2), care delivery and public health (TS), and health policy ('74).

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
5KL2TR001063-03
Application #
8865731
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Wilde, David B
Project Start
2013-09-26
Project End
2016-04-30
Budget Start
2015-05-01
Budget End
2016-04-30
Support Year
3
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Tufts University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
Craig, Alexa K; Gerwin, Roslyn; Bainter, Janelle et al. (2018) Exploring Parent Experience of Communication About Therapeutic Hypothermia in the Neonatal Intensive Care Unit. Adv Neonatal Care 18:136-143
May, Teresa L; Riker, Richard R; Seder, David B (2018) Complex Legacy of the Target Temperature Management Trial. Crit Care Med 46:1864-1865
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Ladin, Keren; Buttafarro, Katie; Hahn, Emily et al. (2018) ""End-of-Life Care? I'm not Going to Worry About That Yet."" Health Literacy Gaps and End-of-Life Planning Among Elderly Dialysis Patients. Gerontologist 58:290-299
Ladin, Keren; Pandya, Renuka; Kannam, Allison et al. (2018) Discussing Conservative Management With Older Patients With CKD: An Interview Study of Nephrologists. Am J Kidney Dis 71:627-635
Ladin, Keren; Daniels, Alexis; Osani, Mikala et al. (2018) Is social support associated with post-transplant medication adherence and outcomes? A systematic review and meta-analysis. Transplant Rev (Orlando) 32:16-28
May, Teresa L; Riker, Richard R; Fraser, Gilles L et al. (2018) Variation in Sedation and Neuromuscular Blockade Regimens on Outcome After Cardiac Arrest. Crit Care Med 46:e975-e980
Riley, Hayden; Headley, Samuel; Winter, Christa et al. (2018) Effect of Smoking Status on Exercise Perception and Intentions for Cardiac Rehabilitation Enrollment Among Patients Hospitalized With an Acute Cardiac Condition. J Cardiopulm Rehabil Prev 38:286-290
Ladin, Keren; Lin, Naomi; Hahn, Emily et al. (2017) Engagement in decision-making and patient satisfaction: a qualitative study of older patients' perceptions of dialysis initiation and modality decisions. Nephrol Dial Transplant 32:1394-1401

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