Contact PD/PI: VERBALIS, JOSEPH G Inst-Career-Dev-001 (378) PROJECT ABSTRACT The program builds on lessons learned from our prior experience in operating a highly successful ?small hub? KL2 program, expands our proven strategies for mentor/mentee training, for enhancing skills in collaboration and team science, and for engaging potential junior faculty scholars into clinical and translational research before they would normally be able to compete for a K-funded position. We propose new collaborations with nearby CTSA Hubs and to continue to design and evaluate novel training experiences to then be shared with the national CTSA consortium. Our program leverages a meshwork of collaborations with all of the other cores in our Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) Hub and is tightly integrated and synergistic with our TL1 pre- and postdoctoral programs. We draw upon a richly-qualified applicant pool from Georgetown and Howard Universities and from MedStar Health that is diverse with respect to prior scientific and professional training, discipline, translational stage(s), research focus, gender, race and ethnicity. This diversity informs our highly individualized and competency-based training program, anchored by equally-diverse dual/team mentorship in order to favor the pursuit of collaborative interdisciplinary team science addressing important health disparities. Our KL2 career development program aims to 1) guide the mentored research career development of exceptionally-promising junior faculty translational investigators from any discipline, department, or eligible institution within GHUCCTS; 2) individualize the development and training plans for each KL2 Scholar, while ensuring a common core of values and behaviors in the responsible conduct of research, skills in team science, and core competencies in translational research; and 3) enrich the pipeline and community of junior faculty translational scholars, especially from groups historically underrepresented in biomedical research, by design and expansion of workshops, courses, mentored experiences and novel training methods for our scholars and for those not yet ready to compete for KL2 support or in other career pathways, so that they all may contribute to rigorous and impactful translational research. We propose an evaluation plan that focused on both program process and outcomes for scholars (during and after training), mentors, curricula, educational experiences, program leadership and administration along with specific metrics and advisory committee input in order to favor critical revision and continued improvement of the proposed career development program. NARRATIVE Improvements in individual and public health depend on engaging and training a multidisciplinary cadre of scientists from multiple disciplines and with diverse perspectives and then encouraging and supporting them to come together in highly functioning teams to tackle important and unsolved problems in human and community health. Only then can we translate the explosion of new knowledge from basic biomedical research to actually develop the diagnostic procedures, preventive measures, treatments, and practice guidelines and policies to lessen the burden of disease and improve the health of every American, in every community, across the lifespan. We have developed, and seek to continue, a career development program for junior faculty scientists to enable them to contribute to this research. Page 888 Project Summary/Abstract Contact PD/PI: VERBALIS, JOSEPH G Inst-Career-Dev-001 (378)

Public Health Relevance

Improvements in individual and public health depend on engaging and training a multidisciplinary cadre of scientists from multiple disciplines and with diverse perspectives and then encouraging and supporting them to come together in highly functioning teams to tackle important and unsolved problems in human and community health. Only then can we translate the explosion of new knowledge from basic biomedical research to actually develop the diagnostic procedures, preventive measures, treatments, and practice guidelines and policies to lessen the burden of disease and improve the health of every American, in every community, across the lifespan. We have developed, and seek to continue, a career development program for junior faculty scientists to enable them to contribute to this research. Page 889 Project Narrative

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Mentored Career Development Award (KL2)
Project #
2KL2TR001432-06
Application #
10086550
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Brazhnik, Olga
Project Start
2015-08-28
Project End
2025-03-31
Budget Start
2020-04-23
Budget End
2021-03-31
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Georgetown University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057
Al-Muhtasib, Nour; Sepulveda-Rodriguez, Alberto; Vicini, Stefano et al. (2018) Neonatal phenobarbital exposure disrupts GABAergic synaptic maturation in rat CA1 neurons. Epilepsia 59:333-344
Sheppard, Vanessa B; de Mendoza, Alejandra Hurtado; He, Jun et al. (2018) Initiation of Adjuvant Endocrine Therapy in Black and White Women With Breast Cancer. Clin Breast Cancer 18:337-346.e1
Talisman, Nicholas W; Hurtado-de-Mendoza, Alejandra; Saunders, Pamela A et al. (2018) Validation of a Standardized Patient Checklist for Patient-Centered Communication: The G-PACER. Med Sci Educ 28:367-373
Ryu, Rachel J; Easterling, Thomas R; Caritis, Steve N et al. (2018) Prednisone Pharmacokinetics During Pregnancy and Lactation. J Clin Pharmacol 58:1223-1232
Wexler, Deborah J; Powe, Camille E; Barbour, Linda A et al. (2018) Research Gaps in Gestational Diabetes Mellitus: Executive Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Obstet Gynecol 132:496-505
Lee, Yichien; Rodriguez, Olga C; Albanese, Chris et al. (2018) Divergent brain changes in two audiogenic rat strains: A voxel-based morphometry and diffusion tensor imaging comparison of the genetically epilepsy prone rat (GEPR-3) and the Wistar Audiogenic Rat (WAR). Neurobiol Dis 111:80-90
Dunn, Raymond; Queenan, Bridget N; Pak, Daniel T S et al. (2018) Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia. Epilepsy Res 140:1-7
Elorette, Catherine; Forcelli, Patrick A; Saunders, Richard C et al. (2018) Colocalization of Tectal Inputs With Amygdala-Projecting Neurons in the Macaque Pulvinar. Front Neural Circuits 12:91
Hurtado-de-Mendoza, Alejandra; Serrano, Adriana; Zhu, Qi et al. (2018) Engaging Latina breast cancer survivors in research: building a social network research registry. Transl Behav Med 8:565-574
Balakrishnan, Poojitha; Vaidya, Dhananjay; Voruganti, V Saroja et al. (2018) Genetic Variants Related to Cardiometabolic Traits Are Associated to B Cell Function, Insulin Resistance, and Diabetes Among AmeriCan Indians: The Strong Heart Family Study. Front Genet 9:466

Showing the most recent 10 out of 86 publications