This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.A number of adverse changes occur to the cardiovascular (heart and blood vessels) and nervous systems with advancing age. The mechanisms (biological reasons) underlying these changes are unknown. However, we do know that: a) increases in the generation of 'oxygen free radicals' (oxygen molecules with a single electron produced by normal metabolism) can cause similar adverse changes that can be observed in patients with certain cardiovascular diseases; and b) the production of these oxygen free radicals increases with advancing age. In addition, we also know that regular aerobic exercise is associated with improved cardiovascular and nervous system function as well as lower production of oxygen free radicals. Accordingly, the proposed research will test the hypothesis that the adverse changes in cardiovascular and nervous system funcion with aging is due to the increased production of oxygen free radicals, whereas the more optimal function associated with regular exercise is due to lower production. This will be determined by administering a potent antioxidant (vitamin C) to reduce the level of 'oxidative stress' (levels of oxygen free radicals) in young and older sedentary men and women, and in endurance exercise trained older adults while measuring cardiovascular and nervous system functions before and after this administration.
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