Diets rich in cruciferous vegetables such as broccoli are associated with a reduced risk of cancer. Animal studies have identified sulforaphane, an isothiocyanate, as the ingredient in broccoli responsible for protection against cancer. This is a randomized, double-blind, placebo controlled inpatient evaluation of the safety and tolerance of broccoli sprout isothiocyanates or glucosinolates (the inert form of isothiocyanates stored in intact plants). Four escalating dose levels of broccoli sprout preparations (25, 100 micromol glucosinolate; 25, 100 micromol isothiocyanate) will be studied in a sequential fashion, each level in a cohort of four healthy volunteers (3 active, 1 placebo). There is a five day washout, seven day dosing, and final seven day washout period. Subjects are maintained throughout the study on a diet free of glucosinolates and isothiocyanates. Doses are given every eight hours for a total of 21 doses. Blood is collected before, during and after dosing, and sent for a battery of hematology and chemistry studies. Urine for assay of isothiocyanates and metabolites is collected continuously throughout the entire study, in 8 hr intervals.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000052-40
Application #
6457937
Study Section
Special Emphasis Panel (ZRR1)
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
40
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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