This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The project aims to determine whether a novel method of assessing bone structure through computerized analysis of digitized bone radiographs (texture analysis) improves our ability to diagnose bone fragility and follow response to treatment for osteoporosis. The study proposed in this CRC application will examine whether texture analysis changes during antiresorptive therapy in a way that can be used clinically for assessing treatment response. Central bone density of the lumbar spine and the femoral neck, peripheral bone density of the heel, texture analysis of the digitized images of os calcis and biochemical markers of bone turnover will be examined every 6 months for 2 years in 20 women receiving calcium supplementation and Alendronate ( 70 mg once weekly) and in 20 control women receiving only calcium supplements. The results of this study will be used to determine whether antiresorptive therapy influences texture analysis, and to determine if combined texture analysis and heel BMD can accurately assess response to antiresorptive therapy and do so as well as currently used methods including central densitometry and/or measurement of biochemical markers.
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