This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Genetics of Salt Sensitive Hypertension Study is designed to examine genetics in salt-sensitive hypertensive African-American siblings as well as to further define cellular and molecular mechanisms of salt-sensitive hypertension. 500 African-American sibships with stage 1 and/or 2 hypertension will receive a low sodium diet, less than 20 meq, for 1 week. The participants will have a complete history, physical and laboratory evaluation including genotyping. If necessary, such participants will also be asked to stop current anti-hypertensive medication and will be started on another (Adalat) for 3 weeks. After such, the patients are instructed to stop all anti-hypertensive medication to prepare for the diet phase of the study which will also last for 1 week. Throughout the study the patients have frequent blood pressure checks. Prior to release from the study, patients are medically evaluated and pre-study anti-hypertensive medication resumed, if necessary. Primary care physicians are notified of patient participation. About 350 control participants and parents of siblings in the study are recruited as well. Their participation is limited to a brief medical history, blood pressure evaluation and/or a blood draw for genotyping.
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