This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.ABSTRACTHYPOTHESESThe farnesyltransferase inhibitor, R115777, will function as a radiosensitizing agent in patients with brainstem gliomas. In addition, ras-mediated anti-tumor activity will be observed in brainstem gliomas following treatment with R115777.
SPECIFIC AIMS Primary Objectives1. To estimate the MTD of R115777 when administered to pediatric patients with nondisseminated, diffuse, intrinisc brainstem gliomas concurrently with radiation therapy with a limited dose escalation.2. To assess the efficacy of R115777 treatment in combination with radiation therapy for patients with non-dissemianted, diffuse, intrinsic pontine gliomas as measured by progression-free survival.Secondary Objectives3. To characterize toxicities associated with R115777 in combination with radiation therapy.4. To characterize radiographic changes in brainstem gliomas treated with radiation and R115777 using MRI, MRS, perfusion and diffusion imaging and PET scans.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000188-44
Application #
7717657
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2007-12-01
Project End
2008-11-30
Budget Start
2007-12-01
Budget End
2008-11-30
Support Year
44
Fiscal Year
2008
Total Cost
$446
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030
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