Abstract

It is claimed that chlorpropamide causes hyponatremia in approximately 4% of patients who are treated with this drug for diabetes insipidus. The present study is designed to help clarify the effect of age on the water retaining actions of this and other sultonylureas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000229-25
Application #
3885840
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
25
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Upstate Medical University
Department
Type
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210

  Publications

Streeten, D H (1995) Idiopathic edema. Pathogenesis, clinical features, and treatment. Endocrinol Metab Clin North Am 24:531-47
Breslau, N A; Weinstock, R S (1988) Regulation of 1,25 (OH)2D synthesis in hypoparathyroidism and pseudohypoparathyroidism. Am J Physiol 255:E730-6
Haas, D C; Anderson Jr, G H; Streeten, D H (1985) Role of angiotensin in lethal cerebral hypoperfusion during treatment of acute hypertension. Arch Intern Med 145:1922-4