Abstract

Some studies have suggested that insulin resistance and the concomitant compensatory hyperinsulinemia are the underlying pathogenetic mechanism of hypertension in whites. The few studies that have examined this hypothesis in African-Americans have produced conflicting results. Compared to whites, African-Americans have a two fold higher prevalence of hypertension. The mechanisms underlying these racial differences are unclear. The overall purpose of the proposed study is to investigate the relation of insulin levels to hypertension in a bi-racial cohort at high risk of developing hypertension. The importance of preventing hypertension in persons with a high normal blood pressure was emphasized by the recent JNC-V and Primary Prevention of Hypertension reports. We will also explore precursors of higher insulin levels during a 2-hour glucose tolerance test over 6 years of follow-up.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
General Clinical Research Centers Program (M01)
Project #
5M01RR000722-24
Application #
2353422
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
24
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Tipton, Laura; Cuenco, Karen T; Huang, Laurence et al. (2018) Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model. BioData Min 11:12
Juraschek, Stephen P; Woodward, Mark; Sacks, Frank M et al. (2017) Time Course of Change in Blood Pressure From Sodium Reduction and the DASH Diet. Hypertension 70:923-929
Anderegg, Nanina; Johnson, Leigh F; Zaniewski, Elizabeth et al. (2017) All-cause mortality in HIV-positive adults starting combination antiretroviral therapy: correcting for loss to follow-up. AIDS 31 Suppl 1:S31-S40
Tang, Olive; Miller 3rd, Edgar R; Gelber, Allan C et al. (2017) DASH diet and change in serum uric acid over time. Clin Rheumatol 36:1413-1417
Juraschek, Stephen P; Miller 3rd, Edgar R; Weaver, Connie M et al. (2017) Effects of Sodium Reduction and the DASH Diet in Relation to Baseline Blood Pressure. J Am Coll Cardiol 70:2841-2848
Segal, Leopoldo N; Clemente, Jose C; Tsay, Jun-Chieh J et al. (2016) Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype. Nat Microbiol 1:16031
Aziz, Najib; Detels, Roger; Quint, Joshua J et al. (2016) Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions. Cytokine 84:17-24
Cribbs, Sushma K; Uppal, Karan; Li, Shuzhao et al. (2016) Correlation of the lung microbiota with metabolic profiles in bronchoalveolar lavage fluid in HIV infection. Microbiome 4:3
Juraschek, Stephen P; Gelber, Allan C; Choi, Hyon K et al. (2016) Effects of the Dietary Approaches to Stop Hypertension (DASH) Diet and Sodium Intake on Serum Uric Acid. Arthritis Rheumatol 68:3002-3009
Aziz, Najib; Detels, Roger; Chang, L Cindy et al. (2016) Macrophage Inflammatory Protein-3 Alpha (MIP-3?)/CCL20 in HIV-1-Infected Individuals. J AIDS Clin Res 7:

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