Abstract

The Tumor and Metastasis Biology Section of the Pediatric Oncology Branch is involved in the study of the biology and therapy of metastasis, primarily in childhood cancers. Our approach to the problem of metastasis is founded in the development, characterization and use of relevant in vivo (animal) models of metastasis. These models include transplantable tumor models, genetically engineered mouse models of metastasis, and naturally occurring cancers that develop in companion animals. The breadth of in vivo expertise provided by our section provides us with a unique and informative perspective on the problem of metastasis. The study of companion animal cancers is facilitated through the Center for Cancer Research - Comparative Oncology Program (http://ccr.nci.nih.gov/resources/cop/). The use of several model systems to study problems in metastasis provides an opportunity to emphasize strengths and minimize weaknesses of a single model system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010566-02
Application #
7291883
Study Section
(POB)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Guimond, Martin; Freud, Aharon G; Mao, Hsiaoyin C et al. (2010) In vivo role of Flt3 ligand and dendritic cells in NK cell homeostasis. J Immunol 184:2769-75
Leaner, Virna D; Chick, Jeffrey F; Donninger, Howard et al. (2009) Inhibition of AP-1 transcriptional activity blocks the migration, invasion, and experimental metastasis of murine osteosarcoma. Am J Pathol 174:265-75
Hong, Sung-Hyeok; Briggs, Joseph; Newman, Rachel et al. (2009) Murine osteosarcoma primary tumour growth and metastatic progression is maintained after marked suppression of serum insulin-like growth factor I. Int J Cancer 124:2042-9
Mendoza, Martin; Khanna, Chand (2009) Revisiting the seed and soil in cancer metastasis. Int J Biochem Cell Biol 41:1452-62
Ren, L; Hong, S H; Cassavaugh, J et al. (2009) The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC. Oncogene 28:792-802
Mushinski, J Frederic; Nguyen, Phuongmai; Stevens, Lisa M et al. (2009) Inhibition of tumor cell motility by the interferon-inducible GTPase MxA. J Biol Chem 284:15206-14
Werner, Sebastian; Mendoza, Arnulfo; Hilger, Ralf A et al. (2008) Preclinical studies of treosulfan demonstrate potent activity in Ewing's sarcoma. Cancer Chemother Pharmacol 62:19-31
Merlino, Glenn; Khanna, Chand (2007) Fishing for the origins of cancer. Genes Dev 21:1275-9
Merchant, Melinda S; Melchionda, Fraia; Sinha, Manoj et al. (2007) Immune reconstitution prevents metastatic recurrence of murine osteosarcoma. Cancer Immunol Immunother 56:1037-46
Whiteford, Craig C; Bilke, Sven; Greer, Braden T et al. (2007) Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis. Cancer Res 67:32-40

Showing the most recent 10 out of 22 publications