This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Objective: To determine the reliability of the neurological and psychometric evaluations for dementia in Down syndrome (DS) by telemedicine (TM) vs. a traditional clinic setting. Rationale: DS provides a model for dementia of the AD type by virtue of the ubiquity of neuropathological findings of the disorder by age 40 years and similarities to AD in regard to Abeta deposition (1, 2). Individuals with DS have been identified as an underserved population in regard to aging and dementia (3). Often individuals with DS live in community sites that do not have access to major medical centers where clinical drug trials are taking place. In this sense, they share common factors with individuals who have AD and who live in diverse populations that are not being accessed by clinical trials.
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