This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.
SPECIFIC AIMS :
AIM 1. To determine what effect daytime sleepiness has on cognitive dysfunction in individuals who abuse methamphetamine. To probe these effects, we will separate subjects into two groups, one that receives temazepam to improve nighttime sleep, and one that receives placebo. As a positive control, subjects will be given modafinil on one day of the study. HYPOTHESIS 1: Subjects who receive temazepam will have improved nighttime sleep (resulting in longer sleep latency on the multiple sleep latency test). Reduced daytime sleepiness will result in improved scores on tests of cognitive function.
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