This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose performing a series of clinical experiments designed to evaluate the role of ethnicity in the metabolic regulation of PAI-1 activity as well as other adipocyte metabolic parameters to evaluate how this might contribute to the relative cardioprotective benefit observed in individuals of Hispanic ethnicity. The studies will specifically address the following areas: (1) How does the regulation of PAI-1 and other adipocyte metabolic parameters differ in Hispanic and non-Hispanic Whites with respect to regional differences in adiposity, PAI-1 genotype, and metabolic parameters? (2) What are the effects of meal composition on PAI-1 levels and other metabolic parameters in Hispanic and non-Hispanic Whites with type 2 diabetes.
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