Abstract

The purpose of this contract is to provide support for a colony of rhesus macaques used in aging and diabetes research. The colony consists of both pre-diabetic and diabetic monkeys from the ages of 7 years to over 30 years. The colony is characterized extensively for parameters of aging and metabolism. These animals are made available to investigators outside of the University of Maryland through collaboration with or request to the P.I. Tissue and blood samples are also available through ODAAR's extensive tissue bank and prospective sampling.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research and Development Contracts (N01)
Project #
N01AG002100-001
Application #
6358756
Study Section
Project Start
1999-10-01
Project End
2000-09-30
Budget Start
2000-09-20
Budget End
2001-09-30
Support Year
Fiscal Year
2000
Total Cost
$734,392
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Physiology
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Johannesdottir, Fjola; Aspelund, Thor; Reeve, Jonathan et al. (2013) Similarities and differences between sexes in regional loss of cortical and trabecular bone in the mid-femoral neck: the AGES-Reykjavik longitudinal study. J Bone Miner Res 28:2165-76
Ortmeyer, Heidi K; Sajan, Mini P; Miura, Atsushi et al. (2011) Insulin signaling and insulin sensitizing in muscle and liver of obese monkeys: peroxisome proliferator-activated receptor gamma agonist improves defective activation of atypical protein kinase C. Antioxid Redox Signal 14:207-19
Ortmeyer, Heidi K; Adall, Yohannes; Marciani, Karina R et al. (2005) Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeys. Am J Physiol Regul Integr Comp Physiol 288:R1509-17
Kim, Sahng Y; Johnson, Mary A; McLeod, D Scott et al. (2005) Neutrophils are associated with capillary closure in spontaneously diabetic monkey retinas. Diabetes 54:1534-42
Liao, Peter; Bodkin, Noni; Cho, Eugene et al. (2004) Minimally invasive surgery via laparoscopy for intra-abdominal biopsy in obese rhesus macaques (Macaca mulatta). Comp Med 54:159-64
Tigno, Xenia T; Gerzanich, Georgielle; Hansen, Barbara C (2004) Age-related changes in metabolic parameters of nonhuman primates. J Gerontol A Biol Sci Med Sci 59:1081-8
Angeloni, Stephen V; Glynn, Nicole; Ambrosini, Grazia et al. (2004) Characterization of the rhesus monkey ghrelin gene and factors influencing ghrelin gene expression and fasting plasma levels. Endocrinology 145:2197-205
Kim, Sahng Y; Johnson, Mary A; McLeod, D Scott et al. (2004) Retinopathy in monkeys with spontaneous type 2 diabetes. Invest Ophthalmol Vis Sci 45:4543-53
Bodkin, Noni L; Alexander, Theresa M; Ortmeyer, Heidi K et al. (2003) Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction. J Gerontol A Biol Sci Med Sci 58:212-9
Hansen, B C (2001) Introduction. Symposium: Calorie restriction: effects on body composition, insulin signaling and aging. J Nutr 131:900S-902S