Abstract

This study is to provide an indepth assessment of a community-based sample of persons who have been previously classified as either having senile dementia or to be high risk for having this disorder. The study includes a clinical examination plus a surveillance by contacting the subject and a close relative or friend every nine months. Comparison will be made with unaffected persons to define risk factors and etiologic events. This is a five year study of a free living population having been identified as positive for senile dementia by a standard screening instrument. The cases and controls will have a clinical examination with valid and quantified measurement techniques and interviews every nine months to obtain demographic, social-psychological, cognitive, medical, drug usage information and health service utilization, and other related information. Similar information will be gathered from a relative or close friend.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Research and Development Contracts (N01)
Project #
N01AG012106-008
Application #
3590693
Study Section
Project Start
1981-06-30
Project End
1988-06-30
Budget Start
1987-09-25
Budget End
1988-06-30
Support Year
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Smith, Christopher G; Fisher, David; Harris, Rebecca et al. (2015) Analyses of 7,635 Patients with Colorectal Cancer Using Independent Training and Validation Cohorts Show That rs9929218 in CDH1 Is a Prognostic Marker of Survival. Clin Cancer Res 21:3453-61
Chen, Jiu-Chiuan; Wang, Xinhui; Wellenius, Gregory A et al. (2015) Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study. Ann Neurol 78:466-76
Danhauer, Suzanne C; Legault, Claudine; Bandos, Hanna et al. (2013) Positive and negative affect, depression, and cognitive processes in the Cognition in the Study of Tamoxifen and Raloxifene (Co-STAR) Trial. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 20:532-52
Rapp, Stephen R; Espeland, Mark A; Manson, Joann E et al. (2013) Educational attainment, MRI changes, and cognitive function in older postmenopausal women from the Women's Health Initiative Memory Study. Int J Psychiatry Med 46:121-43
Pottala, James V; Espeland, Mark A; Polreis, Jason et al. (2012) Correcting the effects of -20 °C storage and aliquot size on erythrocyte fatty acid content in the Women's Health Initiative. Lipids 47:835-46
Espeland, Mark A; Miller, Michael E; Goveas, Joseph S et al. (2011) Cognitive function and fine motor speed in older women with diabetes mellitus: results from the women's health initiative study of cognitive aging. J Womens Health (Larchmt) 20:1435-43
Seshadri, Sudha; Beiser, Alexa; Au, Rhoda et al. (2011) Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2. Alzheimers Dement 7:35-52
Brookmeyer, Ron; Evans, Denis A; Hebert, Liesi et al. (2011) National estimates of the prevalence of Alzheimer's disease in the United States. Alzheimers Dement 7:61-73
Espeland, Mark A; Brunner, Robert L; Hogan, Patricia E et al. (2010) Long-term effects of conjugated equine estrogen therapies on domain-specific cognitive function: results from the Women's Health Initiative study of cognitive aging extension. J Am Geriatr Soc 58:1263-71
Jaramillo, Sarah A; Felton, Deborah; Andrews, Leeann et al. (2007) Enrollment in a brain magnetic resonance study: results from the Women's Health Initiative Memory Study Magnetic Resonance Imaging Study (WHIMS-MRI). Acad Radiol 14:603-12

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